Seunanden Tamlyn Carmin, Ngwenya Nothando, Seeley Janet
School of Nursing and Public Health, Discipline of Public Health Medicine, University of KwaZulu-Natal, Durban, South Africa.
Africa Health Research Institute, KwaZulu-Natal, Durban, South Africa.
BMC Public Health. 2025 Apr 17;25(1):1450. doi: 10.1186/s12889-025-22579-6.
Young people in sub-Saharan Africa (SSA) shoulder a disproportionate burden of global HIV. We conducted a scoping review to map the research on the experiences and perceptions of young people living with HIV (YPLHIV) on antiretroviral therapy (ART) in SSA to inform future research.
Following scoping review guidelines, we searched PubMed, Web of Science, EBSCOhost including Academic Search Complete, APA PsycInfo, Health Source: Nursing/Academic Edition, Medline with Full-text, Scopus and ScienceDirect for papers on YPLHIV adhering and not adhering to ART in SSA. We included literature published between 1 January 2010 and 30 September 2022. Search terms employed were adherence, non-adherence, and related synonyms. Bibliometric data and themes describing factors influencing the experiences and perceptions of ART adherence and non-adherence were extracted.
Of the 2671 papers identified, 22 papers from 12 countries were included. Studies employed quantitative (3), mixed (6), and qualitative (13) methods. Most publications concentrated on barriers to adherence rather than enablers. Factors affecting ART adherence and non-adherence were psychosocial, emotional, self-management, support, financial and structural. YPLHIV also faced problems with the responsiveness of health services and access to information.
We identified multiple factors surrounding ART adherence and non-adherence impacting the health and wellbeing of YPLHIV. The review findings showed the importance of research to improve the understanding of the relationships that YPLHIV in SSA develop with ART in adolescence and factors that facilitate adherence. Psychosocial adherence support and patient-centred care approaches are required.
撒哈拉以南非洲地区（SSA）的年轻人承担着全球艾滋病病毒（HIV）感染的不成比例的负担。我们进行了一项范围综述，以梳理关于SSA地区感染HIV的年轻人（YPLHIV）对抗逆转录病毒疗法（ART）的经历和看法的研究，为未来研究提供参考。
按照范围综述指南，我们在PubMed、科学网、EBSCOhost（包括学术搜索完整版）、美国心理学会心理学文摘数据库、护理/学术版健康源数据库、全文版医学期刊数据库、Scopus和ScienceDirect中搜索关于SSA地区YPLHIV坚持和不坚持ART治疗的论文。我们纳入了2010年1月1日至2022年9月30日发表的文献。使用的检索词包括依从性、不依从性及相关同义词。提取了文献计量数据以及描述影响ART依从性和不依从性经历与看法的因素的主题。
在识别出的2671篇论文中，纳入了来自12个国家的22篇论文。研究采用了定量（3篇）、混合（6篇）和定性（13篇）方法。大多数出版物关注的是依从性的障碍而非促进因素。影响ART依从性和不依从性的因素包括心理社会、情感、自我管理、支持、经济和结构方面。YPLHIV在医疗服务响应性和信息获取方面也面临问题。
我们确定了围绕ART依从性和不依从性的多个因素，这些因素影响着YPLHIV的健康和福祉。综述结果表明，开展研究以增进对SSA地区YPLHIV在青春期与ART之间关系以及促进依从性的因素的理解具有重要意义。需要心理社会依从性支持和以患者为中心的护理方法。
