Chaĭchenko G M
Zh Vyssh Nerv Deiat Im I P Pavlova. 1985 Mar-Apr;35(2):253-60.
Total destruction of the septum, the dorsal hippocampus (DH), or the lesion of the DH combined with that of the medial septal nucleus in rats was shown to facilitate elaboration of conditioned avoidance responses in a shuttle-box due to an increase of general excitability of the animals, and to cause significant impairment of internal inhibition formation. Lesions of the medial or the lateral septal nuclei as well as a combined lesion of the DH and the lateral septal nucleus had no significant effect on conditioning and internal inhibition elaboration. Therefore the septo-hippocampal connections had different functional directions during active defensive behaviour.
结果表明，完全损毁大鼠的中隔、背侧海马（DH），或损毁DH并联合损毁内侧隔核，会因动物整体兴奋性增加而促进穿梭箱中条件性回避反应的形成，并导致内抑制形成显著受损。内侧或外侧隔核的损毁，以及DH和外侧隔核的联合损毁，对条件反射和内抑制的形成均无显著影响。因此，在主动防御行为过程中，隔-海马连接具有不同的功能方向。
