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[杏仁复合体核破坏后大鼠的内抑制]

[Internal inhibition in rats after destruction of amygdaloid complex nuclei].

作者信息

Bogach P G, Makarchuk N E, Chaĭchenko G M

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1981 Jul-Aug;31(4):771-9.

PMID:7303899
Abstract

In experiments on male albino rats bilateral lesions of the basolateral amygdala (BLA) impaired extinction and differentiation of the food-procuring conditioned reflexes where as bilateral corticomedial (CMA) lesions had no effect on them. The BLA damage caused a significant impairment of the aversive stimuli discrimination but had no effect on the extinction of the conditioned avoidance reflex in a shuttle-box. The CMA lesions in both hemispheres led to attenuation of aversive stimuli discrimination and delay of avoidance extinction. The data obtained testify to the BLA dominant role in internal inhibition of the alimentary conditioned reflexes and the CMA dominant role in internal inhibition of avoidance conditioning and furthermore to the importance of BLA in the evaluation of the emotional significance and biological validity of the stimuli (reward or punishment).

摘要

在对雄性白化大鼠进行的实验中,基底外侧杏仁核(BLA)的双侧损伤损害了获取食物的条件反射的消退和分化,而双侧皮质内侧(CMA)损伤对其没有影响。BLA损伤导致厌恶刺激辨别能力显著受损,但对穿梭箱中条件性回避反射的消退没有影响。双侧半球的CMA损伤导致厌恶刺激辨别能力减弱和回避消退延迟。所获得的数据证明了BLA在食物性条件反射的内抑制中起主导作用,CMA在回避条件反射的内抑制中起主导作用,此外还证明了BLA在评估刺激(奖励或惩罚)的情感意义和生物学有效性方面的重要性。

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