Shaw Ranjay, Singh Ashmita, Althagafi Ismail, Pratap Ramendra, Yadav Dharmendra Kumar
Department of Chemistry, GLA University Mathura 281406 India.
Department of Chemistry, University of Delhi Delhi India 110007
RSC Adv. 2025 Apr 17;15(16):12202-12245. doi: 10.1039/d5ra01579k. eCollection 2025 Apr 16.
Alkynes are central in crafting pharmaceuticals, agrochemicals, and materials owing to their reactivity and linear geometry. This review unveils cutting-edge advancements in the stereo-divergent functionalization of alkynes, transforming them into invaluable tools for synthesizing stereochemically defined alkenes and alkanes. The review highlights ground-breaking methodologies that achieve exceptional - and -selectivity using innovative catalysts like cobalt, nickel, and palladium through hydrogenation, hydroboration, and hydrosilylation. Recent breakthroughs such as dual-catalytic systems and energy transfer catalysis enable unprecedented stereocontrol. Sustainable strategies including water as a hydrogen source and recyclable catalysts align with green chemistry principles, paving the way for eco-friendly synthesis. This synthesis of cutting-edge techniques and their applications inspire new avenues in synthetic chemistry, offering transformative tools for creating complex molecular architectures with precision and sustainability.
由于炔烃的反应活性和线性几何结构，它们在药物、农用化学品和材料的制备中起着核心作用。本综述揭示了炔烃立体发散官能团化的前沿进展，将其转化为合成具有立体化学定义的烯烃和烷烃的宝贵工具。该综述重点介绍了一些开创性的方法，这些方法通过使用钴、镍和钯等创新催化剂，通过氢化、硼氢化和硅氢化反应实现了优异的立体选择性。双催化体系和能量转移催化等近期突破实现了前所未有的立体控制。包括以水为氢源和可回收催化剂在内的可持续策略符合绿色化学原则，为环境友好型合成铺平了道路。这种前沿技术的综合及其应用激发了合成化学的新途径，为精确且可持续地创建复杂分子结构提供了变革性工具。
