Liu Ying-Ling, Liu Jie
Department of Gastroenterology, The First Affiliated Hospital of University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, Anhui Province, China.
World J Gastroenterol. 2025 Apr 14;31(14):105420. doi: 10.3748/wjg.v31.i14.105420.
This letter addresses the recently published manuscript by Darnindro , which investigates the diversity and composition of colonic mucosal microbiota in Indonesian patients with and without colorectal cancer (CRC). Although the analysis revealed no statistically significant differences in alpha diversity between the CRC and non-CRC groups, the authors identified notable distinctions in the composition and diversity of colonic mucosal microbiota among patients with CRC compared to those without. At the genus level, a statistically significant difference in microbiota composition was documented between the two cohorts. Specifically, the genera , , , and were found to be elevated in individuals with CRC, while , , and were more prevalent in the non- CRC group.
这封信针对的是达宁德罗最近发表的手稿，该手稿调查了患有和未患有结直肠癌（CRC）的印度尼西亚患者结肠黏膜微生物群的多样性和组成。尽管分析显示CRC组和非CRC组之间的α多样性没有统计学上的显著差异，但作者发现，与未患CRC的患者相比，患CRC的患者结肠黏膜微生物群的组成和多样性存在显著差异。在属水平上，两个队列之间的微生物群组成存在统计学上的显著差异。具体而言，发现属、、和在CRC患者中升高，而、和在非CRC组中更为普遍。
