Han Zong-Qiang, Wen Li-Na
Department of Laboratory Medicine, Beijing Xiaotangshan Hospital, Beijing 102211, China.
Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
World J Gastroenterol. 2025 Jun 7;31(21):106057. doi: 10.3748/wjg.v31.i21.106057.
A case-control study on the differences in colonic mucosa-associated microbiotas between patients with and without colorectal cancer (CRC) in the Indonesian population was recently published. The geographical distribution characteristics of the gut microbiota in the carcinogenic microenvironment are closely related to disease progression. Therefore, the results of that study are of great significance for determining the pathogenesis of CRC in the Indonesian region and for clinically diagnosing and treating CRC. While acknowledging the strengths of the study, its limitations should also be addressed. Future case-control studies of the gut microbiota based on specific populations should be further refined to provide more optimized guidance for clinical precision treatment.
最近发表了一项关于印度尼西亚人群中结直肠癌（CRC）患者与非CRC患者结肠黏膜相关微生物群差异的病例对照研究。致癌微环境中肠道微生物群的地理分布特征与疾病进展密切相关。因此，该研究结果对于确定印度尼西亚地区CRC的发病机制以及临床诊断和治疗CRC具有重要意义。在认可该研究优势的同时，也应指出其局限性。未来基于特定人群的肠道微生物群病例对照研究应进一步完善，为临床精准治疗提供更优化的指导。
