Microbiota geography in the colorectal carcinoma microenvironment: A spatiotemporal atlas of colonic mucosal microbial niche reconstruction.

A case-control study on the differences in colonic mucosa-associated microbiotas between patients with and without colorectal cancer (CRC) in the Indonesian population was recently published. The geographical distribution characteristics of the gut microbiota in the carcinogenic microenvironment are closely related to disease progression. Therefore, the results of that study are of great significance for determining the pathogenesis of CRC in the Indonesian region and for clinically diagnosing and treating CRC. While acknowledging the strengths of the study, its limitations should also be addressed. Future case-control studies of the gut microbiota based on specific populations should be further refined to provide more optimized guidance for clinical precision treatment.