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从孕期到产后:与妊娠期糖尿病相关的心血管风险

From Pregnancy to Postpartum: The Cardiovascular Risks Associated with Gestational Diabetes.

作者信息

Sharma Ramsha, Singh Ujjawal, Kamal Raj, Kumar Ranjeet

机构信息

Department of Pharmacy Practice, ISF College of Pharmacy, Moga, India.

Department of Pharmaceutical Quality Assurance, ISF College of Pharmacy, Moga, India.

出版信息

Curr Cardiol Rev. 2025 Apr 17. doi: 10.2174/011573403X354645250329171327.

Abstract

Cardiovascular disease is the leading cause of pregnancy-related mortality, with pregnancy-related cardiovascular issues extending into the postpartum period. Recent studies suggest hyperandrogenism alters sex hormone levels, contributing to gestational cardiovascular disease CVD. Most of the factors behind the onset of CVD in postpartum women remain unknown. Animal studies mimic adverse pregnancy outcomes to explore molecular causes of severe prenatal cardiac events and their role in postpartum cardiovascular disease development. This review will be focused on summarising human and animal research that shows how undesirable pregnancy outcomes, such as obesity in the mother and gestational diabetes (GD), have an impact on postpartum cardiovascular disease and prenatal cardiometabolic dysfunction. We will highlight the adverse effects of gestational hyperandrogenism as a potential biomarker for cardiovascular dysfunction in pregnant women and new mothers. Investigative cardiovascular (CV) risk variables in the early postpartum phase following pregnancy that were impacted by GD was the aim of this study. Current research strongly implies that women with GDM have a higher risk of developing CVD. Finding appropriate, reliable indicators of CVD and specific treatment modalities that can control obesity, diabetes, and metabolic syndrome are critical to reducing the burden of CVD on impacted women. GD and hypertensive disorders are two pregnancy- related illnesses that raise the risk of CVD in the long run. Despite a lack of awareness, early screening, lifelong monitoring, and continuous research to enhance detection and prevention are essential.

摘要

心血管疾病是与妊娠相关死亡的主要原因,与妊娠相关的心血管问题会持续到产后阶段。最近的研究表明,雄激素过多会改变性激素水平,导致妊娠期心血管疾病(CVD)。产后女性发生CVD的大多数原因仍不清楚。动物研究模拟不良妊娠结局,以探索严重产前心脏事件的分子原因及其在产后心血管疾病发展中的作用。本综述将重点总结人类和动物研究,这些研究表明不良妊娠结局,如母亲肥胖和妊娠期糖尿病(GD),如何影响产后心血管疾病和产前心脏代谢功能障碍。我们将强调妊娠期雄激素过多的不良影响,将其作为孕妇和新妈妈心血管功能障碍的潜在生物标志物。本研究的目的是调查妊娠后产后早期受GD影响的心血管(CV)风险变量。目前的研究强烈表明,患有妊娠期糖尿病(GDM)的女性患CVD的风险更高。找到合适、可靠的CVD指标和能够控制肥胖、糖尿病和代谢综合征的特定治疗方式,对于减轻受影响女性的CVD负担至关重要。GD和高血压疾病是两种与妊娠相关的疾病,从长远来看会增加患CVD的风险。尽管缺乏认识,但早期筛查、终身监测以及持续研究以加强检测和预防至关重要。

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