Ikkala E, Myllylä G, Pelkonen R, Rasi V, Viinikka L, Ylikorkala O
Acta Med Scand. 1985;217(5):507-11. doi: 10.1111/j.0954-6820.1985.tb03254.x.
We have studied haemostatic parameters in 12 patients with Cushing's syndrome. Three patients had prolonged bleeding times, and in all seven patients whose bleeding times were measured 3-6 months after surgical treatment the postoperative bleeding times were shorter (mean 7.5 min) than the pretreatment times (mean 12.3 min). In ADP- or adrenaline-induced aggregation the second wave was lacking in six and the degree of aggregation was borderline or subnormal in five patients. One patient had, in addition, a severe defect in collagen-induced aggregation. However, thromboxane B2 production of the platelets from both endogenous and exogenous arachidonic acid was unaffected. Factor VIII:C, RAg and Rcof activities were all elevated, and in patients with severe disease F VIIIR:Ag and F VIII:Rcof activities were markedly more elevated than F VIII:C activity. The changes in both primary haemostasis and in factor VIII activities correlated clearly with the clinical severity of the disease.
我们研究了12例库欣综合征患者的止血参数。3例患者出血时间延长，在接受手术治疗3 - 6个月后测量出血时间的所有7例患者中，术后出血时间（平均7.5分钟）比治疗前时间（平均12.3分钟）短。在由二磷酸腺苷（ADP）或肾上腺素诱导的聚集反应中，6例患者缺乏第二波，5例患者的聚集程度处于临界或低于正常水平。此外，1例患者在胶原诱导的聚集反应中存在严重缺陷。然而，内源性和外源性花生四烯酸诱导的血小板血栓素B2生成未受影响。因子VIII:C、相关抗原（RAg）和相关协同因子（Rcof）活性均升高，在重症患者中，因子VIIIR:Ag和因子VIII:Rcof活性比因子VIII:C活性升高更为明显。原发性止血和因子VIII活性的变化与疾病的临床严重程度明显相关。
