La Brocca A, Terzolo M, Pia A, Paccotti P, De Giuli P, Angeli A
Divisione di Medicina Interna, Ospedale Civile di Giaveno, Torino, Italy.
J Endocrinol Invest. 1997 Apr;20(4):211-4. doi: 10.1007/BF03346905.
The present report describes a 54-year-old woman with a history of recurrent thromboembolic events. The clinical and physical examination led to suspect Cushing's syndrome. Screening tests (urinary free cortisol excretion and 1 mg dexamethasone) were inconclusive, but a detailed endocrine work up confirmed the presence of ACTH-dependent hypercortisolism. The patient was cured by the removal of a ACTH-secreting microadenoma by transsphenoidal route. The present case provides a clinical demonstration of a previous experimental evidence that a hypercoagulable state is present in Cushing's syndrome.
本报告描述了一名有复发性血栓栓塞事件病史的54岁女性。临床和体格检查怀疑为库欣综合征。筛查试验（尿游离皮质醇排泄和1毫克地塞米松试验）结果不明确，但详细的内分泌检查证实存在促肾上腺皮质激素（ACTH）依赖性皮质醇增多症。通过经蝶窦途径切除分泌ACTH的微腺瘤，患者得以治愈。本病例为先前实验证据提供了临床证明，即库欣综合征存在高凝状态。
