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改善阿片类物质使用障碍患者粮食不安全状况的新型干预措施:一项随机临床试验。

Novel intervention to improve food insecurity among individuals with opioid use disorder: A randomized clinical trial.

作者信息

Sigmon Stacey C, Batchelder Sydney R, Badger Gary J

机构信息

Larner College of Medicine, University of Vermont, Burlington, VT, United States; Departments of Psychiatry, University of Vermont, Burlington, VT, United States; Psychology, University of Vermont, Burlington, VT, United States.

Larner College of Medicine, University of Vermont, Burlington, VT, United States; Departments of Psychiatry, University of Vermont, Burlington, VT, United States.

出版信息

Drug Alcohol Depend. 2025 Jun 1;271:112673. doi: 10.1016/j.drugalcdep.2025.112673. Epub 2025 Apr 8.

Abstract

OBJECTIVE

Food insecurity (FI) is 4-7 times greater among individuals with opioid use disorder (OUD) than the general population and is associated with increased risk for licit and illicit drug use, sexual and drug risk behaviors, infectious disease, and a two-fold odds of premature death. In this randomized study, we evaluated a novel, mail-based meal delivery intervention for improving household FI and other outcomes among individuals with OUD.

METHODS

Fifty adults with FI and OUD were randomized to one of two 12-week experimental conditions: Nutritional Education (NE) involved brief education and assistance with contacting community-based FI-related resources. NE +  Meal Delivery (NE+MD) involved the same education plus weekly premade meals directly from a commercial service. The primary outcome of household FI was measured at monthly assessments, with secondary measures of depression symptoms, quality of life, and biochemically-verified drug use.

RESULTS

The NE+MD intervention was associated with significant improvements in household FI, with rates of FI significantly lower in the NE+MD vs. NE group at all post-intake timepoints (54.6-62.5 % and 90.5-95.2 % among NE+MD and NE groups, respectively; p's < .05). NE+MD participants rated the enjoyment and convenience of meals at 80.7 and 92.8, respectively (range: 0-100). Improvements in FI were also associated with improvements in depression, quality of life and illicit opioid abstinence.

CONCLUSION

This study supports the feasibility, acceptability and initial efficacy of a novel NE+MD intervention for improving household FI among individuals with OUD and provides new preliminary evidence that FI may be associated with participants' mental and physical health.

摘要

目的

阿片类药物使用障碍(OUD)患者的粮食不安全(FI)发生率比普通人群高4至7倍,且与合法和非法药物使用、性和药物风险行为、传染病风险增加以及过早死亡几率翻倍有关。在这项随机研究中,我们评估了一种基于邮件的新型送餐干预措施,以改善患有OUD的个体的家庭FI及其他结果。

方法

50名患有FI和OUD的成年人被随机分配到两个为期12周的实验条件之一:营养教育(NE)包括简短教育以及联系社区FI相关资源的协助。NE + 送餐(NE+MD)包括相同的教育,再加上每周直接从商业服务提供的预制餐。家庭FI的主要结果在每月评估时进行测量,次要测量指标包括抑郁症状、生活质量和经生化验证的药物使用情况。

结果

NE+MD干预与家庭FI的显著改善相关,在所有摄入后时间点,NE+MD组的FI发生率显著低于NE组(NE+MD组和NE组分别为54.6%-62.5%和90.5%-95.2%;p值<0.05)。NE+MD参与者对餐食的喜爱程度和便利性评分分别为80.7和92.8(范围:0-100)。FI的改善还与抑郁、生活质量和非法阿片类药物戒断的改善相关。

结论

本研究支持一种新型NE+MD干预措施在改善患有OUD的个体家庭FI方面的可行性、可接受性和初步疗效,并提供了新的初步证据表明FI可能与参与者的身心健康相关。

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