18例口腔颌面部炎性肌纤维母细胞瘤的临床病理分析
Clinicopathological analysis of 18 cases of inflammatory myofibroblastic tumor in oral and maxillofacial region.
作者信息
Li Wei, Li Meng-Chen, Fan Zi-Xuan, Cao Zi-Chen, Yang Jie, Yang Xu-Dong, Huang Xiao-Feng
机构信息
Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School，Institute of Stomatology, Nanjing University, Nanjing, China.
Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, China.
出版信息
BMC Oral Health. 2025 Apr 18;25(1):591. doi: 10.1186/s12903-025-05995-3.
OBJECTIVE
To analyze the clinicopathological features of inflammatory myofibroblastic tumor retrospectively and help maxillofacial surgeons to improve their recognition of its early diagnosis and proper treatment.
METHODS
Data of 18 patients diagnosed with IMT in Nanjing Stomatological Hospital from November 2003 to July 2024 were collected. Their clinical, pathological, imaging features, treatment, and prognosis were analyzed.
RESULTS
Main clinical manifestations were local masses, 8 cases were accompanied with malignant signs such as pain. No obvious systemic symptoms were reported. Bone destructions were seen in 3 cases. Pathological examination showed that 12 cases were Type II IMT and 6 cases were Type I IMT. 15 cases underwent surgical resections and were followed up for at least 1 years without recurrence.
CONCLUSIONS
The clinical symptoms and imaging manifestations of head and neck IMT are not specific. It is necessary to diagnose IMT by biopsy before operation. Wide local excision is the most reliable treatment.
目的
回顾性分析炎性肌纤维母细胞瘤的临床病理特征，帮助颌面外科医生提高对其早期诊断和合理治疗的认识。
方法
收集2003年11月至2024年7月在南京口腔医院确诊为炎性肌纤维母细胞瘤的18例患者的数据。分析其临床、病理、影像学特征、治疗及预后情况。
结果
主要临床表现为局部肿块，8例伴有疼痛等恶性征象。未报告明显全身症状。3例出现骨质破坏。病理检查显示，12例为Ⅱ型炎性肌纤维母细胞瘤，6例为Ⅰ型炎性肌纤维母细胞瘤。15例行手术切除，术后随访至少1年无复发。
结论
头颈部炎性肌纤维母细胞瘤的临床症状和影像学表现不具有特异性。术前需通过活检诊断炎性肌纤维母细胞瘤。广泛局部切除是最可靠的治疗方法。
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