范可尼贫血患者口腔白斑的高功率激光治疗：病例系列报告
High-Power Laser Treatment for Oral Leukoplakia in Fanconi Anemia: A Case Series Report.
作者信息
Vendruscolo Joana Leticia, Pereira Halina Grossmann, Schussel Juliana Lucena, Torres-Pereira Cassius Carvalho
机构信息
Department of Stomatology, Federal University of Parana, Curitiba, Brazil.
出版信息
Spec Care Dentist. 2025 Mar-Apr;45(2):e70035. doi: 10.1111/scd.70035.
INTRODUCTION
Fanconi Anemia (FA) is a rare genetic disorder with high susceptibility to oral squamous cell carcinoma (SCC). Oral leukoplakia (OL) is frequent in FA patients and lacks a defined treatment. High-power diode lasers (HPDL) offer precise, minimally invasive ablation with favorable healing. This paper reports HPDL use in OL management in FA patients.
CASE REPORT
Four FA patients (1742 years) with clinically and histologically confirmed OL underwent HPDL ablation (808 nm, 1.52 W). Lesions were removed with a 0.5 mm safety margin. All cases showed good healing, no recurrences within 1218 months, and minimal discomfort. Two lesions had dysplasia; one patient had prior SCC.
DISCUSSION/CONCLUSION: HPDL showed favorable short-term outcomes for OL in FA patients. Though limited by small sample and follow-up, the approach may delay malignant transformation. Further studies are needed to confirm long-term benefits.
引言
范可尼贫血（FA）是一种罕见的遗传性疾病，对口腔鳞状细胞癌（SCC）具有高度易感性。口腔白斑（OL）在FA患者中很常见，且缺乏明确的治疗方法。高功率二极管激光器（HPDL）可提供精确、微创的消融治疗，且愈合良好。本文报道了HPDL在FA患者OL治疗中的应用。
病例报告
4例年龄在17至42岁之间、经临床和组织学确诊为OL的FA患者接受了HPDL消融治疗（808纳米，1.52瓦）。病变切除时保留0.5毫米的安全边缘。所有病例均愈合良好，在12至18个月内无复发，且不适轻微。2个病变有发育异常；1例患者曾患SCC。
讨论/结论：HPDL对FA患者的OL显示出良好的短期疗效。尽管受样本量小和随访时间的限制，该方法可能会延迟恶性转化。需要进一步研究以证实其长期益处。
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