Vena J E, Graham S, Zielezny M, Swanson M K, Barnes R E, Nolan J
Am J Epidemiol. 1985 Sep;122(3):357-65. doi: 10.1093/oxfordjournals.aje.a114116.
The authors used data on patients aged 30-79 years admitted to the Roswell Park Memorial Institute in Buffalo, New York, 1957-1965, to compare the amount of lifetime occupational physical activity for 210 white male patients with cancer of the colon and 276 white male patients with cancer of the rectum to the lifetime occupational physical exercise of 1,431 patients with nonneoplastic nondigestive diseases. The authors found that risk of cancer of the colon increased with increasing amount and proportion of time in jobs involving only sedentary or light work. This relationship was not found for rectal cancer. These findings corroborate those of Garabrant et al. (Am J Epidemiol 1984; 119:1005-14). The strength of the associations presented here and the dose-response relationship indicate that limited physical activity could be an important etiologic factor. More inquiries need to be undertaken to study exercise in relation to other factors, such as diet, in colon cancer risk.
作者利用1957年至1965年间纽约州布法罗市罗斯韦尔公园纪念研究所收治的30至79岁患者的数据，比较了210名患有结肠癌的白人男性患者和276名患有直肠癌的白人男性患者的终身职业体力活动量与1431名患有非肿瘤性非消化系统疾病患者的终身职业体育锻炼量。作者发现，结肠癌风险随着仅涉及久坐或轻度工作的职业中工作时间的增加和比例的上升而增加。直肠癌未发现这种关系。这些发现证实了Garabrant等人的研究结果（《美国流行病学杂志》1984年；119:1005 - 14）。此处呈现的关联强度和剂量反应关系表明，体力活动受限可能是一个重要的病因因素。需要进行更多调查来研究运动与结肠癌风险中其他因素（如饮食）的关系。
