Adland-Davenport P, McKenzie M W, Notelovitz M, McKenzie L C, Pendergast J F
Am J Obstet Gynecol. 1985 Jul 15;152(6 Pt 1):630-4. doi: 10.1016/s0002-9378(85)80035-1.
This retrospective study of 54 postmenopausal women taking thiazide diuretics found that bone mineral measurements and bone fracture prevalence did not differ significantly from those of matched control subjects. Matching on the variables of type of menopause (surgical/nonsurgical), years postmenopausal, duration of estrogen therapy (if any), daily intake of dietary and supplemental calcium and vitamin D, and Quetelet index was done without knowledge of the bone mineral measurements. Bone mass was recorded as the bone mineral content and bone density of the distal and midshaft radius. Only fractures associated with osteoporosis (hip, rib, vertebrae, and wrist) were recorded. This study suggests that thiazide diuretics do not provide protection against osteoporosis.
这项针对54名服用噻嗪类利尿剂的绝经后女性的回顾性研究发现，其骨矿物质测量结果和骨折患病率与匹配的对照受试者相比，并无显著差异。在不知道骨矿物质测量结果的情况下，根据绝经类型（手术/非手术）、绝经后年限、雌激素治疗持续时间（如有）、饮食和补充钙及维生素D的每日摄入量以及体重指数等变量进行匹配。骨量记录为桡骨远端和中段的骨矿物质含量和骨密度。仅记录与骨质疏松症相关的骨折（髋部、肋骨、椎骨和腕部）。这项研究表明，噻嗪类利尿剂不能预防骨质疏松症。
