Wasnich R D, Benfante R J, Yano K, Heilbrun L, Vogel J M
N Engl J Med. 1983 Aug 11;309(6):344-7. doi: 10.1056/NEJM198308113090605.
The thiazide diuretics are known to cause calcium retention. In order to study the effect of thiazides on bone mineralization, we have measured the mineral content of bone at five sites (the distal radius, the distal ulna, the proximal radius, the proximal ulna, and the os calcis) in 1368 men with a mean age of 68 years, including 323 who were taking thiazides for hypertension. The results were adjusted for age and body-mass index. Thiazide users had significantly more bone mineral content at all five sites than did non-users. Untreated hypertensive patients and persons without hypertension had comparable bone mineral content, indicating that the higher mineral content found among thiazide users is related to the drug and not to the underlying hypertension. These findings suggest the possibility of a preventive or therapeutic role for thiazides in osteoporosis.
已知噻嗪类利尿剂会导致钙潴留。为研究噻嗪类药物对骨矿化的影响，我们测量了1368名平均年龄为68岁男性五个部位（桡骨远端、尺骨远端、桡骨近端、尺骨近端和跟骨）的骨矿物质含量，其中323人因高血压正在服用噻嗪类药物。结果根据年龄和体重指数进行了调整。服用噻嗪类药物者在所有五个部位的骨矿物质含量均显著高于未服用者。未经治疗的高血压患者和无高血压者的骨矿物质含量相当，这表明服用噻嗪类药物者中较高的矿物质含量与药物有关，而非潜在的高血压。这些发现提示噻嗪类药物在骨质疏松症中具有预防或治疗作用的可能性。
