Michalakis Nicholas P, Patel Archit, Awais Muhammad
Internal Medicine, Piedmont Macon Medical Center, Macon, USA.
Graduate Medical Education, Piedmont Macon Medical Center, Macon, USA.
Cureus. 2025 Mar 19;17(3):e80829. doi: 10.7759/cureus.80829. eCollection 2025 Mar.
Autoimmune hepatitis (AIH) is a complex disease with a chronic cell-mediated immunologic process against healthy liver cells. The clinical presentation can vary since the exact cause of AIH is multifactorial. Here, we report a case of a 61-year-old woman with a past medical history of post-traumatic stress disorder and hypothyroidism who presented clinically with diffuse abdominal distention, nausea, vomiting, jaundice, rash on the torso and legs, and tea-burnt orange urine. The patient underwent an initial workup with a complete blood count (CBC), comprehensive metabolic panel (CMP), and gamma-glutamyl transpeptidase (GGT), with results leading towards a mixed intra- and extrahepatic process. This report will show various findings related to AIH to improve the detection and treatment of these patients early on.
自身免疫性肝炎（AIH）是一种复杂的疾病，其特征是针对健康肝细胞的慢性细胞介导免疫过程。由于AIH的确切病因是多因素的，其临床表现可能各不相同。在此，我们报告一例61岁女性病例，该患者有创伤后应激障碍和甲状腺功能减退的既往病史，临床症状为弥漫性腹胀、恶心、呕吐、黄疸、躯干和腿部皮疹以及浓茶色尿液。患者接受了包括全血细胞计数（CBC）、综合代谢指标（CMP）和γ-谷氨酰转肽酶（GGT）在内的初步检查，结果提示存在肝内和肝外混合性病变。本报告将展示与AIH相关的各种发现，以尽早改善对这些患者的检测和治疗。
