Al-Namaeh Mashael
Clinical Research, Clinical Virtual Research Center, Wayne, USA.
Cureus. 2025 Mar 19;17(3):e80846. doi: 10.7759/cureus.80846. eCollection 2025 Mar.
Meta-analysis is a powerful tool in evidence-based medicine, allowing researchers to synthesize findings from multiple studies to enhance clinical decision-making. This technical report provides a step-by-step guide on conducting a meta-analysis using JASP (Jeffreys's Amazing Statistics Program, University of Amsterdam, Amsterdam, Netherlands), an open-source statistical software. Two case studies illustrate its application: (1) an analysis of the association between serum vitamin D levels and intraocular pressure in primary open-angle glaucoma (POAG) and (2) an evaluation of the relationship between cardiovascular mortality and open-angle glaucoma (OAG). The study follows PRISMA guidelines and employs a random-effects model to account for heterogeneity. Results indicate no significant association between vitamin D and POAG (p = 0.122), while the cardiovascular disease-glaucoma meta-analysis shows high heterogeneity (I² = 99.54%). These findings highlight the challenges of interpreting meta-analyses with variable datasets. This report serves as a practical resource for researchers and clinicians, providing essential tools to conduct meta-analyses effectively and apply them in healthcare research.
荟萃分析是循证医学中的一项强大工具，它使研究人员能够综合多项研究的结果，以加强临床决策。本技术报告提供了一份使用JASP（杰弗里斯神奇统计程序，荷兰阿姆斯特丹大学）进行荟萃分析的分步指南，JASP是一款开源统计软件。两个案例研究说明了其应用：（1）原发性开角型青光眼（POAG）患者血清维生素D水平与眼压之间关联的分析，以及（2）心血管死亡率与开角型青光眼（OAG）之间关系的评估。该研究遵循PRISMA指南，并采用随机效应模型来处理异质性。结果表明维生素D与POAG之间无显著关联（p = 0.122），而心血管疾病 - 青光眼的荟萃分析显示出高度异质性（I² = 99.54%）。这些发现凸显了用可变数据集解释荟萃分析的挑战。本报告为研究人员和临床医生提供了实用资源，提供了有效进行荟萃分析并将其应用于医疗保健研究的重要工具。
