Department of Neurobiology, Care Sciences and Society, Division of Family Medicine and Primary Care, Karolinska Institutet, Alfred Nobels Allé 23, 141 83, Huddinge, Sweden.
Academic Primary Health Care Centre, Region Stockholm Region, Stockholm, Sweden.
Int Ophthalmol. 2022 May;42(5):1481-1489. doi: 10.1007/s10792-021-02137-w. Epub 2021 Nov 29.
We aimed to study open-angle glaucoma in association with somatic comorbidities in the total population of adults in Region Stockholm.
The study population included all living persons aged 19 years and above who resided in Stockholm County, Sweden, on 1 January 2017 (N = 1 703 675). Subjects with specified diseases were identified with data from all registered consultations and hospital stays during 2008-2019. As outcome, the risk of being associated with a diagnosis of open-angle glaucoma was identified during 2012-2018. Analyses were performed by gender, controlling for age and socio-economic status. Age-adjusted odds ratios (ORs) with 95% confidence intervals (95% CI) for women and men with open-angle glaucoma, using individuals without this as referents, were calculated. Socio-economic status was assessed based on the neighbourhood the subjects lived in.
In total, 16,299 cases of open-angle glaucoma were identified during 2012-2018, 9204 women and 7095 men. Higher fully adjusted OR (95% CI) for risk of being associated with open-angle glaucoma was for women and men with diabetes 1.138 (1.074-1.207) and 1.216 (1.148-1.289), cancer 1.175 (1.120-1.233) and 1.106 (1.048-1.166), hypertension 1.372 (1.306-1.440) and 1.243 (1.179-1.311); and for women with thyroid diseases 1.086 (1.030-1.146), chronic lung diseases 1.153 (1.093-1.216), and inflammatory arthropathies 1.132 (1.006-1.275). Higher glaucoma incidence was observed in individuals residing in high socio-economic status neighbourhoods.
The risk of glaucoma is increased in some somatic diseases, especially in individuals with diabetes, hypertension and cancer; and in higher socio-economic neighbourhoods as compared to lower socio-economic neighbourhoods.
我们旨在研究斯德哥尔摩地区成年人总体中与躯体共病相关的开角型青光眼。
研究人群包括 2017 年 1 月 1 日居住在瑞典斯德哥尔摩县的所有 19 岁及以上的居民（N=1703675）。通过 2008-2019 年期间所有登记的就诊和住院数据，确定患有特定疾病的患者。作为结果，在 2012-2018 年期间确定了与开角型青光眼诊断相关的风险。通过控制年龄和社会经济地位，对女性和男性的开角型青光眼风险进行分析。使用没有这种疾病的个体作为参考，计算了女性和男性开角型青光眼的年龄调整比值比（OR）和 95%置信区间（95%CI）。社会经济地位是根据患者居住的街区来评估的。
在 2012-2018 年期间，共确定了 16299 例开角型青光眼病例，其中女性 9204 例，男性 7095 例。患有糖尿病的女性和男性的完全调整后的 OR（95%CI）与开角型青光眼相关的风险更高，分别为 1.138（1.074-1.207）和 1.216（1.148-1.289）；患有癌症的女性和男性的 OR 更高，分别为 1.175（1.120-1.233）和 1.106（1.048-1.166）；患有高血压的女性和男性的 OR 更高，分别为 1.372（1.306-1.440）和 1.243（1.179-1.311）；患有甲状腺疾病的女性的 OR 更高，为 1.086（1.030-1.146）；患有慢性肺部疾病的女性和男性的 OR 更高，分别为 1.153（1.093-1.216）和 1.132（1.006-1.275）；患有炎症性关节病的女性的 OR 更高，为 1.132（1.006-1.275）。居住在社会经济地位较高的街区的个体中，青光眼的发病率更高。
某些躯体疾病会增加患青光眼的风险，尤其是患有糖尿病、高血压和癌症的个体；且在社会经济地位较高的街区比在社会经济地位较低的街区的风险更高。
