Maisat Wiriya, Yuki Koichi
Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, USA.
Transl Perioper Pain Med. 2025;12(1):694-696. doi: 10.31480/2330-4871/198. Epub 2025 Feb 10.
Codeine and tramadol are two commonly used opioids for pediatric pain. However, death and severe respiratory distress cases following codeine administration illustrated there would be a significant heterogenous response to these opioids depending on CYP2D6 phenotypes, leading to FDA warning against pediatric use. Here we will comment on the current status of pediatric pain management in the context of codeine and tramadol.
可待因和曲马多是两种常用于治疗儿童疼痛的阿片类药物。然而，服用可待因后出现的死亡和严重呼吸窘迫病例表明，根据CYP2D6基因表型，这些阿片类药物会产生显著的个体差异反应，导致美国食品药品监督管理局（FDA）发出禁止儿童使用的警告。在此，我们将结合可待因和曲马多来评述儿童疼痛管理的现状。
