Sun Yu-Ying, Lin Bing-Ying, Mao Zhen, Liang Xuan-Wei, Zhang Cui-Yu, Huang Dan-Ping, Ni Yao, Li Zuo-Hong
Department of Ophthalmology, the Third Affiliated Hospital of GuangZhou University of Chinese Medicine, Guangzhou 510060, Guangdong Province, China.
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, Guangdong Province, China.
Int J Ophthalmol. 2025 Apr 18;18(4):691-698. doi: 10.18240/ijo.2025.04.16. eCollection 2025.
To evaluate refraction and ocular biological characteristics in children with unilateral congenital ptosis.
In this cross-sectional study, 200 Chinese children (3-15y) with unilateral congenital ptosis were evaluated. Cycloplegic refraction and ocular biological measurements were taken from Oct. 2020 to Aug. 2022.
In patients with congenital ptosis, the prevalence of with-the-rule astigmatism and oblique astigmatism was significantly high. The cornea was flatter in ptotic eyes [K1 (42.37±1.62 42.78±1.51 D), K2 (43.8±1.86 44.2±1.64 D), corneal power (Km; 43.09±1.68 43.49±1.53 D), all <0.001]. Axial length (AL) was longer in ptotic eyes (22.55 22.51 mm, =0.012). The white-to-white (WTW) was significantly smaller in ptotic eyes (11.49 11.65 mm, <0.001). The central corneal thickness (CCT) was greater in ptotic eyes (553.50 545.00 µm, <0.001). No significant differences were found in anterior chamber depth (AD), lens thickness (LT) and vitreous thickness (VT) between ptotic and fellow eyes (>0.05). In addition, the incidence of amblyopia in ptosis eyes was 32.0%, which was significantly higher than that in the normal population.
Ptotic eyes have longer AL, flatter, thicker and smaller corneas than fellow eyes. The congenital ptosis increases the risk of amblyopia. The results suggest that regular examinations of refractive status and ocular biological parameters such as AL, are essential for children with unilateral congenital ptosis.
评估单侧先天性上睑下垂患儿的屈光状态和眼部生物学特征。
在这项横断面研究中，对200例3至15岁的单侧先天性上睑下垂中国儿童进行了评估。于2020年10月至2022年8月进行了睫状肌麻痹验光和眼部生物学测量。
先天性上睑下垂患者中，顺规散光和斜轴散光的患病率显著较高。上睑下垂眼的角膜更扁平[K1（42.37±1.62对42.78±1.51 D），K2（43.8±1.86对44.2±1.64 D），角膜屈光力（Km；43.09±1.68对43.49±1.53 D），均P<0.001]。上睑下垂眼的眼轴长度（AL）更长（22.55对22.51 mm，P=0.012）。上睑下垂眼的角膜横径（WTW）显著更小（11.49对11.65 mm,P<0.001）。上睑下垂眼的中央角膜厚度（CCT）更大（553.50对545.00 µm，P<0.001）。上睑下垂眼与对侧眼之间的前房深度（AD）、晶状体厚度（LT）和玻璃体厚度（VT）无显著差异（P>0.05）。此外，上睑下垂眼的弱视发生率为32.0%，显著高于正常人群。
上睑下垂眼比其对侧眼的眼轴更长，角膜更扁平、更厚且更小。先天性上睑下垂会增加弱视风险。结果表明，对于单侧先天性上睑下垂患儿，定期检查屈光状态和眼部生物学参数如眼轴长度等至关重要。
