Dong Huan, Liu Ye, Wang Xianjing, Liu Ping
The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, People's Republic of China.
J Multidiscip Healthc. 2025 Apr 16;18:2173-2184. doi: 10.2147/JMDH.S517307. eCollection 2025.
The fat-to-muscle mass ratio (FMR) is a novel anthropometric parameter that integrates the antagonistic effects of fat and muscle mass. The current study aimed to examine the associations between total and region-specific FMR with the prevalence of self-reported infertility in US women.
US women aged 20 to 44 years from the 2013-2018 National Health and Nutrition Examination Survey were included. Total, trunk, arm, and leg FMR were calculated from fat mass and muscle mass in the corresponding body part by dual-energy X-ray absorptiometry. Binary logistic regression, restricted cubic spline analysis and subgroup analysis were primarily used for statistical analyses.
Infertility prevalence was 12.77% among the 1958 women included. Arm and leg FMR were not associated with infertility prevalence, while the odds ratio and 95% confidence intervals for infertility by each 0.1 point increase in trunk and total FMR were 1.19 (1.07-1.33) and 1.16 (1.04-1.30), respectively. Restricted cubic spline analysis indicated a positive and linear relationship between trunk or total FMR and infertility prevalence. Subgroup analysis consistently demonstrated that the associations between trunk or total FMR with infertility prevalence were more pronounced in women without a pregnancy history than in those with a pregnancy history. The receiver-operating characteristic curves indicated that the trunk FMR outperformed total, arm, and leg FMR in discriminating infertility from women without infertility.
Trunk and total FMR, rather than arm or leg FMR, were associated with an increased risk of infertility in US women, especially those without a prior pregnancy history.
脂肪与肌肉质量比（FMR）是一种新的人体测量参数，它综合了脂肪和肌肉质量的拮抗作用。本研究旨在探讨总体和特定区域的FMR与美国女性自我报告的不孕症患病率之间的关联。
纳入2013 - 2018年美国国家健康与营养检查调查中年龄在20至44岁的女性。通过双能X线吸收法根据相应身体部位的脂肪量和肌肉量计算总体、躯干、手臂和腿部的FMR。主要采用二元逻辑回归、受限立方样条分析和亚组分析进行统计分析。
纳入的1958名女性中不孕症患病率为12.77%。手臂和腿部FMR与不孕症患病率无关，而躯干和总体FMR每增加0.1个单位，不孕症的优势比及95%置信区间分别为1.19（1.07 - 1.33）和1.16（1.04 - 1.30）。受限立方样条分析表明躯干或总体FMR与不孕症患病率之间呈正线性关系。亚组分析一致表明，躯干或总体FMR与不孕症患病率之间的关联在无妊娠史的女性中比有妊娠史的女性更为明显。受试者工作特征曲线表明，在区分不孕症女性与非不孕症女性方面，躯干FMR优于总体、手臂和腿部FMR。
躯干和总体FMR，而非手臂或腿部FMR，与美国女性不孕症风险增加相关，尤其是那些既往无妊娠史的女性。
