Lotif Mara Assef Leitão, Valadas Lidia Audrey Rocha, Bottenberg Peter, Squassi Aldo, Dantas Thereza Cristina Farias Botelho, Passos Vanara Florêncio, Rodrigues Neto Edilson Martins, Bandeira Mary Anne Medeiros, Fonteles Marta Maria de França
Pharmacy Department, Pharmacy, Dentistry and Nursing College, Federal University of Ceara, 1210 Pastor Samuel Mulunga Street 60430372, Fortaleza, Ceara, Brazil.
Universidad de Buenos Aires, Facultad de Odontología, Cátedra de Odontología Preventiva y Comunitaria, Buenos Aires, Argentina.
Int J Dent. 2025 Apr 10;2025:3414733. doi: 10.1155/ijod/3414733. eCollection 2025.
This study aims to verify the stability of different types of fluoride in a dentifrice containing Brazilian red propolis (BRP). The dentifrice formulation was developed with calcium carbonate (CaCO) and sodium monofluorophosphate (MFP) (patent INPI BR1020170110974). Nominal fluoride content was 1500 μg/g. Batches of five lots were selected and analyzed for 2 consecutive years (fresh, with 12 and 24 months). Dentifrices from each tube were analyzed in duplicate using an ion-specific electrode (ISE). The concentrations of fluoride (total fluoride [TF], total soluble fluoride [TSF], and ionizable fluoride [IF]) were determined, and the results were expressed in ppm F (μgF/g). After 12 months of aging, the samples showed TF concentration ranging from 1198.9 ± 26.9 to 1443.6 ± 33.4 ppm F, TSF ranging from 869.6 ± 105.5 to 965.8 ± 149.8 ppm F, and IF ranging from 223.5 ± 14.8 to 269.7 ± 10.1 ppm F. After 24 months of aging, the samples showed TF concentration ranging from 763.5 ± 73.2 to 1083.1 ± 32.4 ppm F, TSF ranging from 552.3 ± 39.9 to 758.4 ± 141.1 ppm F, and IF ranging from 102.2 ± 4.0 to 174.7 ± 4.9 ppm F. Soluble fluoride remained relatively stable until 12 months of aging; however, at 24 months of aging, the concentration reduced.
本研究旨在验证含巴西红蜂胶（BRP）的牙膏中不同类型氟化物的稳定性。牙膏配方采用碳酸钙（CaCO）和单氟磷酸钠（MFP）（专利号INPI BR1020170110974）。标称氟含量为1500μg/g。选取五批样品，连续两年（新鲜样品、存放12个月和24个月的样品）进行分析。每管牙膏样品使用离子选择性电极（ISE）进行双份分析。测定氟化物浓度（总氟[TF]、总可溶性氟[TSF]和可离子化氟[IF]），结果以ppm F（μgF/g）表示。老化12个月后，样品的TF浓度范围为1198.9±26.9至1443.6±33.4ppm F，TSF范围为从869.6±105.5至965.8±149.8ppm F，IF范围为从223.5±14.8至269.7±10.1ppm F。老化24个月后，样品的TF浓度范围为763.5±73.2至1083.1±32.4ppm F，TSF范围为从552.3±39.9至758.4±141.1ppm F，IF范围为从102.2±4.0至174.7±4.9ppm F。可溶性氟在老化至第12个月时相对稳定；然而，在老化24个月时，其浓度降低。
