Fu Wenxiang, Sun Aijun, Dai Huijuan
Renji School of Clinical Medicine, Shanghai Jiaotong University, Shanghai 200127, China.
Department of Thyroid and Breast Oncological Surgery, The Affiliated Huaian Hospital of Xuzhou Medical University, Huai'an Second People's Hospital, Huai'an, Jiangsu 223001, China.
Genes Dis. 2024 Jul 15;12(4):101376. doi: 10.1016/j.gendis.2024.101376. eCollection 2025 Jul.
Breast cancer is the most common malignant tumor threatening women's health. Alteration in lipid metabolism plays an important role in the occurrence and development of many diseases, including breast cancer. The uptake, synthesis, and catabolism of lipids in breast cancer cells are significantly altered, among which the metabolism of fatty acids, cholesterols, sphingolipids, and glycolipids are most significantly changed. The growth, progression, metastasis, and drug resistance of breast cancer cells are tightly correlated with the increased uptake and biosynthesis of fatty acids and cholesterols and the up-regulation of fatty acid oxidation. Cholesterol and its metabolite 27-hydroxycholesterol promote the progression of breast cancer in a variety of ways. The alteration of lipid metabolism could promote the epithelial-mesenchymal transition of breast cancer cells and lead to changes in the tumor immune microenvironment that are conducive to the survival of cancer cells. While the accumulation of ceramide in cancer cells shows an inhibitory effect on breast cancer. This review focuses on lipid metabolism and elaborates on the research progress of the correlation between different lipid metabolism and the growth, progression, and drug resistance of breast cancer.
乳腺癌是威胁女性健康的最常见恶性肿瘤。脂质代谢改变在包括乳腺癌在内的许多疾病的发生和发展中起着重要作用。乳腺癌细胞中脂质的摄取、合成和分解代谢发生显著改变，其中脂肪酸、胆固醇、鞘脂和糖脂的代谢变化最为显著。乳腺癌细胞的生长、进展、转移和耐药性与脂肪酸和胆固醇摄取及生物合成增加以及脂肪酸氧化上调密切相关。胆固醇及其代谢产物27-羟基胆固醇以多种方式促进乳腺癌进展。脂质代谢改变可促进乳腺癌细胞上皮-间质转化，并导致有利于癌细胞存活的肿瘤免疫微环境变化。而癌细胞中神经酰胺的积累对乳腺癌表现出抑制作用。本综述聚焦脂质代谢，阐述不同脂质代谢与乳腺癌生长、进展及耐药性之间相关性的研究进展。
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