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4D打印技术在药物递送领域推动个性化医疗变革。

Revolutionizing Personalized Medicine with 4D Printing in Drug Delivery.

作者信息

Sharma Nandini, Garg Yukta, Singh Amandeep

机构信息

Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab 142001, India.

出版信息

Curr Drug Deliv. 2025 Apr 18. doi: 10.2174/0115672018388762250414114651.

Abstract

4D printing is an improvement over the traditional 3D printing technique involving the application of dynamic materials that change with the environmental conditions, including temperature, humidity, and pH. This technology holds great promise for drug development to create effective and personalized drug delivery systems. Different from conventional technologies, 4D printed systems can control the administration rate of drugs depending on the internal environment, thus enhancing the effectiveness of treatments and considering adverse effects at the same time effectively. 4D printing contributes to the creation of smart materials for use in vaccines, implants, and other devices that respond to body signals in real-time. However, several hurdles persist in the synthesis and fabrication of these materials as well as their regulatory approval. This technology represents the future of drug manufacturing, emphasizing patient-specific care and providing a more effective, efficient, and adaptive approach to therapeutic delivery.

摘要

4D打印是对传统3D打印技术的改进,它涉及应用随环境条件(包括温度、湿度和pH值)变化的动态材料。这项技术在药物开发方面极具潜力,可用于创建有效且个性化的药物递送系统。与传统技术不同,4D打印系统能够根据内部环境控制药物的给药速率,从而提高治疗效果并同时有效考虑不良反应。4D打印有助于制造用于疫苗、植入物和其他实时响应身体信号的设备的智能材料。然而,在这些材料的合成与制造以及监管审批方面仍存在一些障碍。这项技术代表了药物制造的未来,强调以患者为中心的护理,并为治疗递送提供一种更有效、高效且适应性更强的方法。

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