Millar S W, Thurlow A C, Findley I L
Anaesthesia. 1985 Jul;40(7):687-92. doi: 10.1111/j.1365-2044.1985.tb10954.x.
Indoramin, a competitive alpha 1-adrenoceptor antagonist, was administered intravenously to 12 fit patients aged 20-49 years during general anaesthesia with either halothane or enflurane for ear, nose and throat surgery. A mean decrease of systolic blood pressure of 6 mmHg followed the initial dose of 0.1 mg/kg. Systolic blood pressures of 70-80 mmHg were achieved in nine patients using 0.29-4 mg/kg. The maximum effect of every dose was achieved within 3 minutes, with a probable duration of action of at least 30 minutes. Large changes of heart rate did not occur, though there was gradual slowing of the heart during each series of incremental administrations. Junctional rhythm, sometimes with bradycardia and hypotension, occurred in five patients (four in halothane group; one in enflurane group). Because of this, and the greater than ten-fold variation in decrease of blood pressure for a single weight-related dose, indoramin is not recommended for the reduction of blood pressure during halothane anaesthesia.
吲哚拉明是一种竞争性α1肾上腺素能受体拮抗剂，在12名年龄在20至49岁的健康患者接受氟烷或恩氟烷全身麻醉进行耳鼻喉手术期间，通过静脉注射给予该药。初始剂量为0.1mg/kg后，收缩压平均下降6mmHg。9名患者使用0.29至4mg/kg的剂量后，收缩压达到70至80mmHg。每剂的最大效果在3分钟内达到，作用持续时间可能至少为30分钟。虽然在每次递增给药过程中心脏有逐渐减慢的情况，但心率没有发生大的变化。5名患者出现交界性心律，有时伴有心动过缓和低血压（氟烷组4名；恩氟烷组1名）。因此，以及由于与体重相关的单一剂量导致的血压下降有超过十倍的差异，不推荐在氟烷麻醉期间使用吲哚拉明来降低血压。
