Galli Anaïs, Comparet Marianne, Dagne Daniel Argaw, Baratti-Mayer Denise, Cao Thi H, Guérin Philippe J, Guevara Maria, Hetzel Manuel W, Jeantet Claire, Mpinga Emmanuel Kabengele, Muendane Valter, Okanlawon Mulikat, Placella Erika, Ribes Marta, Sherlock Mark, Utzinger Jürg, Steinmann Peter
Swiss Tropical and Public Health Institute, Allschwil, Switzerland.
University of Basel, Basel, Switzerland.
PLoS Negl Trop Dis. 2025 Apr 21;19(4):e0012940. doi: 10.1371/journal.pntd.0012940. eCollection 2025 Apr.
• A 1-day symposium brought together over 100 individuals with lived experience of noma, expertise in neglected tropical diseases, and public health, including researchers, health advocates, and clinicians. The involvement of noma survivors was invaluable and added an important perspective in defining the research agenda. • The most pressing research needs identified were: ○ Clear case definition of noma ○ Early case detection and robust surveillance ○ Psychosocial and economic impact of noma ○ Decision support for diagnosing acute necrotizing gingivitis and associated antibiotic regimen(s) with treatment duration ○ Deeper understanding of risk factors and social determinants ○ Identification of effective information, education, and communication strategies ○ Effectiveness of surgical services ○ Testing decentralized follow-up for patients • An important conclusion was that noma research and control activities must be integrated across sectors and disciplines, such as neglected tropical diseases, oral health, nutrition, and child health programs including immunization.
• 一场为期一天的研讨会汇聚了100多名有坏疽性口炎亲身经历的人、被忽视热带病领域的专家以及公共卫生领域人士，其中包括研究人员、健康倡导者和临床医生。坏疽性口炎幸存者的参与非常宝贵，为确定研究议程增添了重要视角。
• 确定的最紧迫研究需求包括：
坏疽性口炎的明确病例定义
早期病例检测和强有力的监测
坏疽性口炎的心理社会和经济影响
诊断急性坏死性龈炎及相关抗生素治疗方案（包括治疗持续时间）的决策支持
对危险因素和社会决定因素的更深入理解
确定有效的信息、教育和沟通策略
外科服务的有效性
对患者进行分散式随访测试
• 一个重要结论是，坏疽性口炎的研究和控制活动必须跨部门和学科整合，如被忽视热带病、口腔健康、营养以及包括免疫接种在内的儿童健康项目。
