Etezadi Tahura, Semnani Ali, Ehsani Hodis, Goli Hamid Reza, Samaei Amirreza, Sobouti Farhad
Gen Dent. 2025 May-Jun;73(3):73-77.
The use of mouthwash is a practical approach to decreasing bacteria during orthodontic treatment. This study aimed to investigate the antibacterial effect of 0.2% curcumin mouthwash on in individuals undergoing fixed orthodontic treatment. For this double-blinded clinical study, 22 orthodontic patients aged 15 years or older with no systemic or periodontal diseases were selected and randomly divided into 2 groups of 11 individuals. One group received 0.2% curcumin mouthwash (intervention), while the other group received 0.2% chlorhexidine mouthwash (control) to use twice daily. Orthodontic elastics were collected from the patients' mouth immediately before the first use of the mouthwash, immediately after the first use, and after 20 days of mouthwash use. The elastics were stored in normal saline, and the samples were transferred to a microbiology laboratory for serial dilution, plating, and incubation. After 48 hours, the number of colony-forming units (CFUs) of were counted and compared. The Friedman and Wilcoxon tests were used for statistical analysis of intragroup data, while the Mann-Whitney U test was used for intergroup comparisons. A difference of P < 0.05 was considered statistically significant. Both the curcumin and chlorhexidine groups demonstrated a statistically significant decrease in CFUs of immediately after the initial use as well as after 20 days' use (P < 0.05). After the first use, there was no statistically significant difference between the groups in the reduction of CFUs (P = 0.071). However, after 20 consecutive days of mouthwash use, the curcumin group had a significantly greater decrease in CFUs of than the chlorhexidine group (P < 0.001). Both chlorhexidine and curcumin mouthwashes significantly reduced the number of colonies when used regularly. The results of the present study suggest that curcumin herbal mouthwash is a superior choice to chlorhexidine for orthodontic patients due to its long-term antibacterial properties.
使用漱口水是正畸治疗期间减少细菌的一种实用方法。本研究旨在调查0.2%姜黄素漱口水对接受固定正畸治疗的个体的抗菌效果。在这项双盲临床研究中，选取了22名年龄在15岁及以上、无全身性或牙周疾病的正畸患者，并随机分为两组，每组11人。一组接受0.2%姜黄素漱口水（干预组），而另一组接受0.2%氯己定漱口水（对照组），每天使用两次。在首次使用漱口水前、首次使用后以及使用漱口水20天后，立即从患者口腔中收集正畸弹力圈。将弹力圈储存在生理盐水中，然后将样本转移到微生物实验室进行系列稀释、平板接种和培养。48小时后，计数并比较变形链球菌的菌落形成单位（CFU）数量。Friedman和Wilcoxon检验用于组内数据的统计分析，而Mann-Whitney U检验用于组间比较。P < 0.05被认为具有统计学意义。姜黄素组和氯己定组在首次使用后以及使用20天后，变形链球菌的CFU均有统计学意义的显著下降（P < 0.05）。首次使用后，两组在CFU减少方面无统计学显著差异（P = 0.071）。然而，连续使用漱口水20天后，姜黄素组变形链球菌的CFU下降幅度明显大于氯己定组（P < 0.001）。定期使用时，氯己定和姜黄素漱口水均能显著减少变形链球菌菌落数量。本研究结果表明，由于姜黄素草本漱口水具有长期抗菌特性，对于正畸患者来说，它是比氯己定更好的选择。
