Mounie J, Dumas M, Escousse A
Ann Biol Clin (Paris). 1985;43(3):255-9.
In order to monitor loco-regional anaesthesia in the upper limbs with a combination of two anaesthetics, the authors participated in a clinical pharmacology study. They describe a method of simultaneous assay of bupivacaine and lignocaine by direct phase HPLC. In particular, the use of heptane sulfonic acid (counter-ion) in the mobile phase allows the elution of the local anaesthetics to be controlled. The criteria of reliability studied enable this technique to be considered for routine use.
为了监测上肢联合使用两种麻醉剂时的局部区域麻醉情况，作者参与了一项临床药理学研究。他们描述了一种通过直接相高效液相色谱法同时测定布比卡因和利多卡因的方法。特别是，在流动相中使用庚烷磺酸（反离子）可以控制局部麻醉剂的洗脱。所研究的可靠性标准使该技术可被考虑用于常规使用。
