在优化条件下，HIV阳性母亲的母乳喂养：资源丰富的医疗环境中的“实际”结果。
Breastfeeding in HIV-positive mothers under optimized conditions: 'real-life' results from a well-resourced healthcare setting.
作者信息
Feiterna-Sperling Cornelia, Krüger Renate, Bethke Hannah, Siedentopf Jan-Peter, von Weizsäcker Katharina, Heinrich-Rohr Michaela, Rohr Irena
机构信息
Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt - Universität zu Berlin, Berlin, Germany.
Department of Obstetrics, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt - Universität zu Berlin, Berlin, Germany.
出版信息
J Perinat Med. 2025 Apr 22;53(6):765-774. doi: 10.1515/jpm-2025-0170. Print 2025 Jul 28.
OBJECTIVES
Global guidelines increasingly support breastfeeding among women living with HIV (WLWH) under optimized conditions. However, outcome data from high-resource settings remain limited.
METHODS
We retrospectively analyzed WLWH who delivered at Charité - Universitätsmedizin Berlin between 2017 and 2023. Eligibility for breastfeeding required VL<50 cop/mL.
RESULTS
Of 409 WLWH, 365 (89.2 %) were eligible and 77 (18.8 %) initiated breastfeeding. No case of mother-to-child transmission (MTCT) was observed. Sustained viral suppression and ART adherence were key. Exclusive breastfeeding was associated with longer duration (p=0.001), midwifery care promoted exclusivity (p=0.009), and vaginal delivery was linked to longer duration (p=0.005).
CONCLUSIONS
Breastfeeding with VL<50 cop/mL appears safe in high-resource settings. Findings support individualized counseling, close monitoring, and multidisciplinary care. The increasing breastfeeding trend reflects a shift in clinical practice.
目的
全球指南越来越支持在优化条件下，感染艾滋病毒的妇女（WLWH）进行母乳喂养。然而，高资源环境下的结果数据仍然有限。
方法
我们回顾性分析了2017年至2023年期间在柏林夏里特大学医学中心分娩的感染艾滋病毒的妇女。母乳喂养的条件是病毒载量<50拷贝/毫升。
结果
在409名感染艾滋病毒的妇女中，365名（89.2%）符合条件，77名（18.8%）开始母乳喂养。未观察到母婴传播（MTCT）病例。持续的病毒抑制和抗逆转录病毒治疗依从性是关键。纯母乳喂养与更长的持续时间相关（p=0.001），助产护理促进了纯母乳喂养（p=0.009），阴道分娩与更长的持续时间相关（p=0.005）。
结论
在高资源环境下，病毒载量<50拷贝/毫升的母乳喂养似乎是安全的。研究结果支持个性化咨询、密切监测和多学科护理。母乳喂养趋势的增加反映了临床实践的转变。
Zotero 插件