伊朗裔 Guilan 队列研究人群中腰围臀围比（WHR）与糖尿病的关系。
The association between waist-to-hip ratio (WHR) with diabetes in the PERSIAN Guilan cohort study population.
机构信息
Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
出版信息
BMC Endocr Disord. 2024 Jul 15;24(1):113. doi: 10.1186/s12902-024-01641-1.
BACKGROUND
Waist circumference (WC), or waist-to-hip ratio (WHR), potentially offers a more accurate reflection of intra-abdominal fat accumulation and could serve as a superior predictor of type 2 diabetes mellitus (T2DM) risk compared to BMI. The current study investigated the relationship between WHR and its influencing factors among diabetes patients enrolled in the Prospective Epidemiological Research Studies in Iran (PERSIAN) Guilan Cohort study (PGCS).
METHOD
In this cross-sectional study of 10,520 participants, 2,531 had T2DM. Waist and hip circumference, body mass index (BMI), underlying diseases, and demographical data of participants were recorded. Also, fasting blood sugar (FBS), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides (TG) were assessed. All data was analyzed using SPSS version 16; the significant level was < 0.05.
RESULTS
The mean age of participants was 51.52 ± 8.90 years, and 39.9% had a BMI between 25 and 30 kg/m. The prevalence of diabetes was 24.1% (n = 2531). About 7628 (72.5%) individuals had abnormal WHR, and 2072 (19.7%) were diabetics. Among patients with diabetes, abnormal WHR was significantly associated with age over 50, female gender, higher BMI, and lower LDL (P < 0.05).
CONCLUSION
The study showed a higher prevalence of abnormal WHR in diabetic patients. Abnormal WHR in patients with diabetes was significantly associated with age, gender, and BMI.
背景
腰围（WC）或腰臀比（WHR）可能更能准确反映内脏脂肪堆积情况，并且与 BMI 相比，它可能是预测 2 型糖尿病（T2DM）风险的更好指标。本研究调查了伊朗前瞻性流行病学研究（PERSIAN）吉兰队列研究（PGCS）中登记的糖尿病患者的 WHR 与其影响因素之间的关系。
方法
在这项横断面研究中，共有 10520 名参与者，其中 2531 名患有 T2DM。记录了参与者的腰围和臀围、体重指数（BMI）、基础疾病和人口统计学数据。此外，还评估了空腹血糖（FBS）、低密度脂蛋白（LDL）胆固醇、高密度脂蛋白（HDL）胆固醇和甘油三酯（TG）。所有数据均使用 SPSS 版本 16 进行分析；显著性水平<0.05。
结果
参与者的平均年龄为 51.52±8.90 岁，BMI 在 25 至 30kg/m 之间的占 39.9%。糖尿病的患病率为 24.1%（n=2531）。约 7628（72.5%）个体的 WHR 异常，2072（19.7%）个体患有糖尿病。在患有糖尿病的患者中，异常的 WHR 与年龄大于 50 岁、女性、较高的 BMI 和较低的 LDL 显著相关（P<0.05）。
结论
本研究显示，糖尿病患者中异常 WHR 的患病率较高。糖尿病患者异常的 WHR 与年龄、性别和 BMI 显著相关。
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