Martin D G, Hall J E, Patrick D H
Am J Vet Res. 1985 Jun;46(6):1326-9.
The Wintrobe erythrocyte sedimentation rate (ESR) has been used in animals and persons as a screening test for inflammatory disease and as a monitor for disease progression in individuals. Now, the zetacrit (ZC) and zeta sedimentation ratio (ZSR) are suggested as suitable rapid laboratory tests to replace the ESR in dogs. In 65 dogs, a strong inverse correlation between ESR and ZC was observed (r = -0.961, P less than 0.05). Significant correlations of similar magnitude between ZC and hematocrit (r = 0.587, P less than 0.05) and ESR and Hct (r = 0.569, P less than 0.05) were observed. In addition, influences of various protein fractions, such as fibrinogen, globulin, and albumin, on the ESR and ZC were evaluated and found to be of similar magnitude. These data indicate that ESR and ZC are equivalent methods for determining erythrocyte sedimentation rates in dogs. A strong correlation (r = 0.900, P less than 0.05) between Wintrobe ESR, adjusted for the effect of Hct (ESRHct), and ZSR was observed. The influence of plasma proteins on ESRHct and ZSR was of similar magnitude. However, a weak yet significant correlation between ESRHct and the microhematocrit remained (r = 0.291, P less than 0.05). Data indicate that the latter more effectively factors out the influence of Hct on sedimentation.
温氏红细胞沉降率（ESR）已被用于动物和人类，作为炎症性疾病的筛查试验以及个体疾病进展的监测指标。现在，有人建议使用红细胞压积（ZC）和红细胞沉降比（ZSR）作为合适的快速实验室检测方法，以替代犬类的ESR。在65只犬中，观察到ESR与ZC之间存在强烈的负相关（r = -0.961，P < 0.05）。还观察到ZC与血细胞比容之间存在相似程度的显著相关性（r = 0.587，P < 0.05），以及ESR与血细胞比容之间存在显著相关性（r = 0.569，P < 0.05）。此外，评估了纤维蛋白原、球蛋白和白蛋白等各种蛋白质组分对ESR和ZC的影响，发现其影响程度相似。这些数据表明，ESR和ZC是测定犬类红细胞沉降率的等效方法。观察到校正血细胞比容影响后的温氏ESR（ESRHct）与ZSR之间存在强烈相关性（r = 0.900，P < 0.05）。血浆蛋白对ESRHct和ZSR的影响程度相似。然而，ESRHct与微量血细胞比容之间仍存在微弱但显著的相关性（r = 0.291，P < 0.05）。数据表明，后者能更有效地排除血细胞比容对沉降的影响。
