Crook L, Liu P I, Gadsden R H, Turner R E
Ann Clin Lab Sci. 1980 Sep-Oct;10(5):368-76.
In order to assess the relationships of erythrocyte sedimentation rates (ESR) and various acute phase reactants in diagnosing and following the remissions and exacerbations of various chronic diseases, multiple tests were performed on patients for whom an ESR was ordered. The Wintrobe and Westergren ESR, plasma and serum viscosity, hemoglobin, blood cell indices, fibrinogen, serum protein electrophoresis, triglycerides, and complement (C-3) were performed. A discussion of the relative merits of correcting the Wintrobe ESR by the Wintrobe anemia correction chart of the Hynes and Whitby method is presented. Although many significant correlations exist, only the Wintrobe and Westergren ESRs and plasma viscosity approached the same number of abnormal results. If the results of the Wintrobe and Westergren are combined 67 abnormal results are observed. The plasma viscosity exhibited a 10.4 percent false positive rate compared to the combined ESR's and a 6.0 percent false negative rate. The plasma viscosity was not only highly significantly correlated with the ESR's (P < < 0.001), but also with all acute phase reactants measured as well as total protein, albumin, and gamma-globulin. The plasma viscosity appears to give the best overall summation of the many non-specific changes observed in chronic disease.
为了评估红细胞沉降率（ESR）与各种急性期反应物在诊断和监测各种慢性疾病的缓解与加重情况中的关系，对接受ESR检测的患者进行了多项检测。检测项目包括温氏法和魏氏法ESR、血浆和血清粘度、血红蛋白、血细胞指数、纤维蛋白原、血清蛋白电泳、甘油三酯以及补体（C-3）。文中还讨论了采用海因斯和惠特比方法的温氏贫血校正图校正温氏ESR的相对优点。尽管存在许多显著相关性，但只有温氏法和魏氏法ESR以及血浆粘度出现异常结果的数量相近。如果将温氏法和魏氏法的结果合并，可观察到67个异常结果。与合并后的ESR相比，血浆粘度的假阳性率为10.4%，假阴性率为6.0%。血浆粘度不仅与ESR高度显著相关（P << 0.001），而且与所有检测的急性期反应物以及总蛋白、白蛋白和γ-球蛋白也高度显著相关。血浆粘度似乎能最好地综合反映慢性疾病中观察到的许多非特异性变化。
