Wu Pei-Wen, Chang Po-Hung, Huang Chi-Che, Lee Ta-Jen, Fan Yu-Hsi, Huang Chien-Chia
Division of Rhinology, Department of Otolaryngology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
School of Medicine, Chang Gung University, Taoyuan, Taiwan.
J Asthma Allergy. 2025 Apr 17;18:567-578. doi: 10.2147/JAA.S517258. eCollection 2025.
This study aimed to characterize the clinical features of patients with comorbid asthma and chronic rhinosinusitis with nasal polyps and to evaluate the impact of comorbid asthma on the quality of life of these patients.
Adult patients with bilateral chronic rhinosinusitis with nasal polyps scheduled for sinus surgery were prospectively enrolled. Clinical information of the participants, including laboratory data and computed tomography images. The Sinonasal Outcome Test-22 was used to evaluate nasal symptoms and quality of life impairment of participants.
A total of 170 participants were recruited, of whom 32 (18.8%) had comorbid asthma. Compared to patients with chronic rhinosinusitis with nasal polyps and without comorbid asthma, patients with asthma exhibited significant higher age, computed tomography ethmoid/maxillary ratio, computed tomography olfactory cleft opacification score, serum total IgE, serum eosinophil cationic protein levels, and blood and tissue eosinophil count. Patients with comorbid chronic rhinosinusitis with nasal polyps and asthma exhibited significant higher total, and rhinologic- and sleep-related domains of the Sinonasal Outcome Test-22 than did those without comorbid asthma.
Comorbid asthma is associated with more severe type 2 eosinophilic inflammation and has a significant impact on the nasal symptoms and quality of life of patients with chronic rhinosinusitis with nasal polyps, particularly as shown in the rhinologic- and sleep-related domains of the Sinonasal Outcome Test-22. This information may assist physicians in decision-making when treating these patients.
本研究旨在描述合并哮喘和伴有鼻息肉的慢性鼻-鼻窦炎患者的临床特征，并评估合并哮喘对这些患者生活质量的影响。
前瞻性纳入计划接受鼻窦手术的双侧伴有鼻息肉的慢性鼻-鼻窦炎成年患者。收集参与者的临床信息，包括实验室数据和计算机断层扫描图像。使用鼻窦结局测试-22来评估参与者的鼻部症状和生活质量损害情况。
共招募了170名参与者，其中32名（18.8%）合并哮喘。与患有慢性鼻-鼻窦炎伴鼻息肉但无合并哮喘的患者相比，合并哮喘的患者表现出显著更高的年龄、计算机断层扫描筛窦/上颌窦比值、计算机断层扫描嗅裂混浊评分、血清总IgE、血清嗜酸性粒细胞阳离子蛋白水平以及血液和组织嗜酸性粒细胞计数。合并慢性鼻-鼻窦炎伴鼻息肉和哮喘的患者在鼻窦结局测试-22的总分以及与鼻科和睡眠相关的领域方面，显著高于无合并哮喘的患者。
合并哮喘与更严重的2型嗜酸性粒细胞炎症相关，并且对伴有鼻息肉的慢性鼻-鼻窦炎患者的鼻部症状和生活质量有显著影响，特别是在鼻窦结局测试-22的鼻科和睡眠相关领域中表现明显。这些信息可能有助于医生在治疗这些患者时进行决策。
