Singh Gurmeet, Karsono Ramadhan, Sjamsoe Soedarman, Triono Muhammad Rizki, Nora Rina La Distia, Felicia Devi, Gultom Fajar Lamhot, Ruslim Daniel, Sejati Arif, Gunarsa Ralph Girson, Pitoyo Ceva Wicaksono, Rumende Cleopas Martin
Division of Respirology and Critical Illness, Universitas Indonesia Departemen Ilmu Penyakit Dalam, Rumah Sakit Dr. Cipto Mangunkusumo, Jakarta, Indonesia.
Mochtar Riady Comprehensive Cancer Centre Siloam Hospitals Semanggi, Jakarta, Indonesia.
Case Rep Med. 2025 Apr 14;2025:3219868. doi: 10.1155/carm/3219868. eCollection 2025.
Necrotizing sarcoid granulomatosis (NSG) is a rare disease characterized by granulomatous and necrotic features as well as vasculitis, and it primarily affects the lungs, with occasional extrapulmonary manifestations. The first documented case was in Jakarta, Indonesia. A 71-year-old male presented with prolonged fever, a neck mass, and multiple mediastinal lymphadenopathy. The disease was initially suspected as lung tuberculosis, but a surgical biopsy of the left thyroid lobe confirmed the NSG pattern. Treatment with oral prednisolone led to positive outcomes, as evidenced by radiological improvement at the 3-month follow-up. This case report aims to emphasize the challenges and the importance of clinician awareness in diagnosing NSG.
坏死性结节病样肉芽肿病(NSG)是一种罕见疾病,其特征为肉芽肿性和坏死性特征以及血管炎,主要累及肺部,偶尔有肺外表现。首例有记录的病例发生在印度尼西亚雅加达。一名71岁男性出现持续发热、颈部肿块和多处纵隔淋巴结肿大。该疾病最初被怀疑为肺结核,但左甲状腺叶手术活检证实为NSG模式。口服泼尼松龙治疗取得了积极效果,3个月随访时的影像学改善证明了这一点。本病例报告旨在强调临床医生在诊断NSG时面临的挑战以及提高认识的重要性。