Le Gall F, Loeuillet L, Delaval P, Thoreux P H, Desrues B, Ramée M P
Laboratoire d'Anatomie Pathologique B, Hôpital Pontchaillou, Centre Hospitalier Régional et Universitaire, Rennes, France.
Pathol Res Pract. 1996 Mar;192(3):306-13; discussion 314. doi: 10.1016/S0344-0338(96)80237-8.
Three cases of necrotizing sarcoid granulomatosis (NSG) are reported. All 3 patients had pulmonary lesions; one of them had additional extrapulmonary lesions which were ophthalmologic (dacryoadenitis) and digestive (ulcerative colitis). This patient was followed for 5 years and developed several respiratory, ophthalmologic and digestive recurrences. In 2 cases the diagnosis of NSG had been initially overlooked and the authors emphasize the difficulties of this histologic diagnosis in terms of the differential diagnosis with other necrotic and granulomatous pulmonary diseases such as tuberculosis and Wegener's granulomatosis. They stress the possibility of extrapulmonary lesions in NSG and discuss the relationship between NSG and sarcoidosis.
本文报告了3例坏死性结节病样肉芽肿病（NSG）。所有3例患者均有肺部病变；其中1例有额外的肺外病变，包括眼科病变（泪腺炎）和消化系统病变（溃疡性结肠炎）。该患者随访5年，出现多次呼吸、眼科和消化系统复发。在2例患者中，NSG的诊断最初被忽视，作者强调了这种组织学诊断在与其他坏死性和肉芽肿性肺部疾病（如肺结核和韦格纳肉芽肿病）进行鉴别诊断时的困难。他们强调了NSG发生肺外病变的可能性，并讨论了NSG与结节病之间的关系。
