Lipszyc Romy Tamara, Rodda Christine P, Wright Martin, Duckham Rachel L
Western Clinical School, The University of Melbourne and Western Health, St. Albans, Victoria, Australia.
Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, St. Albans, Victoria, Australia.
J Paediatr Child Health. 2025 Jun;61(6):852-864. doi: 10.1111/jpc.70063. Epub 2025 Apr 22.
Autism spectrum disorder (ASD) is a complex disorder associated with social and communication impairments and repetitive and restrictive behavioural patterns. Children with ASD often present with concurrent conditions, including poor bone health, which affect long-term health. Although there is compelling evidence to suggest that children with ASD have poorer bone traits than typically developing children, the primary factors associated with these differences are unclear. This review will explore the potential role that factors such as physical activity, nutrition (calcium, protein, vitamin C, vitamin D) and lifestyle (sleep, medication) play on bone health in children with ASD. Having a greater understanding of the influencing factors of low BMD and how these might interact in a synergistic manner in ASD children will provide an opportunity to develop targeted interventions to improve bone health aiming to avert attainment of suboptimal peak bone mass which may lead to early onset osteoporosis, fracture and muscle deconditioning in this paediatric population.
自闭症谱系障碍（ASD）是一种复杂的疾病，与社交和沟通障碍以及重复和受限的行为模式有关。患有ASD的儿童常伴有其他病症，包括骨骼健康不佳，这会影响其长期健康。尽管有确凿证据表明，患有ASD的儿童的骨骼特征比正常发育的儿童差，但导致这些差异的主要因素尚不清楚。本综述将探讨身体活动、营养（钙、蛋白质、维生素C、维生素D）和生活方式（睡眠、药物治疗）等因素对患有ASD的儿童骨骼健康的潜在作用。深入了解低骨密度的影响因素以及这些因素在ASD儿童中如何以协同方式相互作用，将为制定有针对性的干预措施提供机会，以改善骨骼健康，避免达到可能导致该儿科人群早期骨质疏松、骨折和肌肉失能的次优峰值骨量。
