Ogata M, Kenmotsu K, Hirota N, Meguro T, Aikoh H
Arch Environ Health. 1985 May-Jun;40(3):151-4. doi: 10.1080/00039896.1985.10545908.
Levels of mercury in the brain and liver of acatalasemic mice immediately following exposure to metallic mercury vapor or injection of metallic mercury were higher than those found in normal mice. Acatalasemic mice had decreased levels of mercury in the blood and kidneys when the levels were compared with those of normal mice, which indicated that catalase plays a role in oxidizing and taking up mercury. Thus, the brain/blood or liver/blood ratio of mercury concentration in acatalasemic mice was significantly higher than that of normal mice. These results suggest that metallic mercury in the blood easily passed through the blood-brain or blood-liver barrier. The levels of mercury distribution to the kidneys of normal and acatalasemic mice, 1 hr after injection of mercuric chloride solution, were higher than that of normal and acatalasemic mice, respectively, 1 hr after injection of metallic mercury.
暴露于金属汞蒸气或注射金属汞后，立即检测无过氧化氢酶小鼠大脑和肝脏中的汞含量，发现其高于正常小鼠。与正常小鼠相比，无过氧化氢酶小鼠血液和肾脏中的汞含量降低，这表明过氧化氢酶在氧化和摄取汞的过程中发挥作用。因此，无过氧化氢酶小鼠大脑/血液或肝脏/血液中的汞浓度比显著高于正常小鼠。这些结果表明，血液中的金属汞很容易穿过血脑屏障或血肝屏障。注射氯化汞溶液1小时后，正常小鼠和无过氧化氢酶小鼠肾脏中的汞分布水平分别高于注射金属汞1小时后的正常小鼠和无过氧化氢酶小鼠。
