Kang Anna, Lee Junbeom, Eor Ju Young, Kwak Min-Jin, Kim Yong-An, Oh Sangnam, Kim Younghoon
Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Science, Seoul National University, Seoul 08826, Korea.
Korea RND Nonghyup, Seoul 04949, Korea.
J Anim Sci Technol. 2025 Mar;67(2):421-438. doi: 10.5187/jast.2024.e22. Epub 2025 Mar 31.
This study conducts a comprehensive analysis of deer antler velvet's impact, with a specific emphasis on mouse models and experiments. The study navigates the intricacies of antler velvet's variability, encompassing considerations of drying methods, extraction techniques, and anatomical regions of antlers. Employing a diverse array of processing methods, this study prioritizes both food safety and the consistent intake of deer antler velvet extracts. The study scrupulously evaluates toxicity and immune-boosting properties through exhaustive assessments, utilizing , immunosuppressive mouse models, and immune cells. The study unfolds the repercussions of deer antler velvet extract on the lifespan, neuromuscular functions, and cognitive abilities of . Additionally, this study explores the extract's potential to alleviate toxicity induced by cyclophosphamide (CPA) in a mouse model, with a focus on inflammation, metabolic disorders, and gut microbiota composition. The antler velvet extract prevents immune dysregulation caused by CPA treatment by ameliorating systemic inflammation and restoring energy metabolism. Furthermore, antler velvet extract treatment significantly transforms the gut microbiota of an immunosuppressive mouse model by fostering the proliferation of commensal bacteria such as , , and at the genus level. Moreover, antler velvet treatment enhances the activity of natural killer cells against YAC-1 lymphoma while tempering overactivity among immune cells to baseline levels. In conclusion, this study provides nuanced insights into the diverse benefits of antler velvet extract, encouraging sustained research to unveil its complete potential in the realms of mouse models and experiments.
本研究对鹿茸的影响进行了全面分析，特别侧重于小鼠模型和实验。该研究探讨了鹿茸变异性的复杂之处，包括干燥方法、提取技术和鹿茸解剖部位等方面的考量。采用多种加工方法，本研究将食品安全和鹿茸提取物的持续摄入放在首位。通过详尽评估，利用免疫抑制小鼠模型和免疫细胞，该研究严谨地评估了毒性和免疫增强特性。该研究揭示了鹿茸提取物对小鼠寿命、神经肌肉功能和认知能力的影响。此外，本研究探讨了该提取物在小鼠模型中减轻环磷酰胺（CPA）诱导的毒性的潜力，重点关注炎症、代谢紊乱和肠道微生物群组成。鹿茸提取物通过改善全身炎症和恢复能量代谢，预防了CPA治疗引起的免疫失调。此外，鹿茸提取物治疗通过促进共生细菌如属水平的、和的增殖，显著改变了免疫抑制小鼠模型的肠道微生物群。此外，鹿茸治疗增强了自然杀伤细胞对YAC-1淋巴瘤的活性，同时将免疫细胞的过度活性调节至基线水平。总之，本研究为鹿茸提取物的多种益处提供了细致入微的见解，鼓励持续开展研究以揭示其在小鼠模型和实验领域的全部潜力。
