Chen Huadi, Zhao Wenting, Xiao Yi, Gao Qiaoping, Yang Xiaoqu, Pang Kangfeng, Huang Baoyi, Liang Xiaolu
Department of Hepatobiliary Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, People's Republic of China.
Development Planning Department, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, People's Republic of China.
Prev Med Rep. 2025 Apr 10;53:103057. doi: 10.1016/j.pmedr.2025.103057. eCollection 2025 May.
To investigate the association between dietary niacin intake and the risk of gallstones in American adults using data from the National Health and Nutrition Examination Survey (NHANES) from 2017 to 2020.
This cross-sectional study analyzed data from 8191 participants aged 18 years and older. Dietary niacin intake was assessed using two 24-h dietary recalls. The presence of gallstones was identified through a questionnaire. Logistic regression models were used to estimate odds ratios (ORs) and 95 % confidence intervals (CIs) for gallstones across quartiles of niacin intake, adjusting for demographic and health-related covariates.
Participants with higher niacin intake showed a significantly lower risk of gallstones. After adjusting for a wide range of covariates, individuals in the highest quartile of niacin intake had a 49 % reduced risk of gallstones compared to those in the lowest quartile (OR = 0.51, 95 % CI: 0.34, 0.76).
Higher dietary niacin intake is associated with a reduced risk of gallstones in US adults. These findings suggest that increasing niacin intake could be a viable strategy for the prevention of gallstones. Future longitudinal studies are needed to confirm these results and explore the underlying mechanisms.
利用2017年至2020年美国国家健康与营养检查调查（NHANES）的数据，研究美国成年人膳食烟酸摄入量与胆结石风险之间的关联。
这项横断面研究分析了8191名18岁及以上参与者的数据。使用两次24小时膳食回顾来评估膳食烟酸摄入量。通过问卷调查确定胆结石的存在。采用逻辑回归模型估计烟酸摄入量四分位数组中胆结石的比值比（OR）和95%置信区间（CI），并对人口统计学和健康相关协变量进行调整。
烟酸摄入量较高的参与者患胆结石的风险显著较低。在对广泛的协变量进行调整后，烟酸摄入量最高四分位数组的个体与最低四分位数组相比，患胆结石的风险降低了49%（OR = 0.51，95% CI：0.34，0.76）。
美国成年人膳食烟酸摄入量较高与胆结石风险降低有关。这些发现表明，增加烟酸摄入量可能是预防胆结石的一种可行策略。需要进一步的纵向研究来证实这些结果并探索潜在机制。
