Yang Jianquan, Guo Wen, Pang Xuezhou, Tang Yuerong, Zhang Yakun, Zeng Beilei, Gui Yan, Ma Daiyuan
Department of Oncology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Pharmacy Department, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Front Oncol. 2025 Apr 8;15:1519922. doi: 10.3389/fonc.2025.1519922. eCollection 2025.
As a common malignant tumor, esophageal cancer is easy to relapse and distant metastasis, and the prognosis is very poor. Colon and rectal metastasis of esophageal cancer is extremely rare. This study reports a case of colorectal and rectal metastasis in an esophageal squamous cell carcinoma patient. The patient was a 65-year-old man who presented with progressive swallowing obstruction. Gastroscopy and pathological biopsy revealed low-differentiated squamous cell carcinoma in the lower esophagus (32cm from the incisor). After completing the relevant examination, the patient was evaluated by the thoracic surgeon and showed no indication of surgery. Then the patient was received 2 cycles of Abraxane plus cisplatin with Sintilimab. After the treatment, the esophageal lesion was examined by Chest CT, and assesses again by the surgeon again and radical radiotherapy was recommended without indication of surgery. After radiotherapy, the patient underwent comprehensive imaging examination. Abdominal CT showed mass in the lower abdomen. Colonoscopy and pathological biopsy showed squamous cell carcinoma of colon and rectum. According to the pathological type and tumor monism, and communication with the pathologist, the patient was diagnosed to be esophageal cancer with rectal and colon metastasis. Through this case report, we hope to deepen the understanding of rare esophageal squamous cell metastasis, and comprehensive examination should be conducted before initial treatment to evaluate the tumor status.
作为一种常见的恶性肿瘤,食管癌容易复发和远处转移,预后很差。食管癌的结肠和直肠转移极为罕见。本研究报告了1例食管鳞状细胞癌患者发生结直肠转移的病例。该患者为65岁男性,表现为进行性吞咽梗阻。胃镜及病理活检显示食管下段(距门齿32cm)低分化鳞状细胞癌。完成相关检查后,经胸外科医生评估,患者无手术指征。随后患者接受了2周期白蛋白结合型紫杉醇联合顺铂及信迪利单抗治疗。治疗后,通过胸部CT检查食管病变,并再次由外科医生评估,建议行根治性放疗,无手术指征。放疗后,患者接受了全面的影像学检查。腹部CT显示下腹部有肿块。结肠镜及病理活检显示结肠和直肠鳞状细胞癌。根据病理类型和肿瘤一元论,并与病理科医生沟通,患者被诊断为食管癌伴直肠和结肠转移。通过本病例报告,我们希望加深对罕见的食管鳞状细胞转移的认识,并且在初始治疗前应进行全面检查以评估肿瘤状态。