芦荟凝胶作为辅助手段用于牙周炎患者机械清创的临床疗效：一项系统评价和荟萃分析。
Clinical effectiveness of aloe vera gel as an adjunct to mechanical debridement in patients with periodontitis: A systematic review and meta-analysis.
作者信息
Ashifa Nisha, Viswanathan Krishnan, Srinivasan Sivapragasam, Pavithran Varsha K, Shankar Shiva, Sundaram Rajasekar, Kumar Senthil, Anusha Divvi
机构信息
Department of Periodontology, Rajah Muthiah Dental College & Hospital, Annamalai University, Annamalai Nagar, Tamil Nadu, India.
Public Health Researcher & Biostatistician, Rypple Foundation Cypresstraat 64, 2565LW Den Haag, India.
出版信息
J Adv Periodontol Implant Dent. 2025 Jan 20;17(1):15-25. doi: 10.34172/japid.2025.002. eCollection 2025 Mar.
BACKGROUND
This study aimed to evaluate the clinical effect of aloe vera gel as an adjunct to scaling and root planing (SRP) on plaque index (PI), gingival index (GI), and probing pocket depth (PPD) in periodontitis treatment.
METHODS
Randomized controlled trials (RCTs) were included, focusing on aloe vera gel as an adjunct to SRP in periodontitis patients. An extensive literature search was conducted across PubMed, PubMed Central, Scopus, OVID, Google Scholar, and Cochrane Library databases up to October 2024. The risk of bias was assessed using the Revised Cochrane Risk of Bias tool (ROB 2.0), and statistical analysis was performed using Review Manager 5.4.1.
RESULTS
Fifteen RCTs were included in this systematic review, and separate meta-analyses were conducted for each outcome. For PI, the random effects model showed a mean difference (MD) of -0.23 (95% CI: -0.69, 0.23), favoring the experimental group (=0.33). The fixed effects model for PI favored the control group (MD=0.12; =0.20). For GI, the random effects model favored the experimental group (MD=-0.28, =0.01), while the fixed effects model favored the control group (MD=0.17; <0.001). For PPD, the random effects model favored the experimental group (MD=-0.45, =0.009).
CONCLUSION
As an adjunct to SRP, aloe vera gel significantly improved PI, GI, and PPD in periodontitis patients.
TRIAL REGISTRATION
PROSPERO ID: CRD42020201315.
背景
本研究旨在评估在牙周炎治疗中，芦荟凝胶作为龈下刮治术和根面平整术（SRP）辅助手段对菌斑指数（PI）、牙龈指数（GI）和探诊深度（PPD）的临床效果。
方法
纳入随机对照试验（RCT），重点关注芦荟凝胶作为牙周炎患者SRP辅助手段的情况。截至2024年10月，在PubMed、PubMed Central、Scopus、OVID、谷歌学术和Cochrane图书馆数据库中进行了广泛的文献检索。使用修订后的Cochrane偏倚风险工具（ROB 2.0）评估偏倚风险，并使用Review Manager 5.4.1进行统计分析。
结果
本系统评价纳入了15项RCT，并对每个结局进行了单独的荟萃分析。对于PI，随机效应模型显示平均差（MD）为-0.23（95%CI：-0.69，0.23），支持试验组（P=0.33）。PI的固定效应模型支持对照组（MD=0.12；P=0.20）。对于GI，随机效应模型支持试验组（MD=-0.28，P=0.01），而固定效应模型支持对照组（MD=0.17；P<0.001）。对于PPD，随机效应模型支持试验组（MD=-0.45，P=0.009）。
结论
作为SRP的辅助手段，芦荟凝胶显著改善了牙周炎患者的PI、GI和PPD。
试验注册
PROSPERO编号：CRD42020201315。
Zotero 插件