生物可吸收性聚乙烯醇-柠檬酸敷料：实验性体内模型中的伤口愈合研究
Bioabsorbable Poly(vinyl alcohol)-Citric Acid Dressings: Wound Healing Studies in an Experimental In Vivo Model.
作者信息
Pereira Jonalba Mendes, Arisawa Emilia Angela Lo Schiavo, Filho Antônio Luiz Martins Maia, Figueredo-Silva José, Alves Nicoly, da Silveira Carolina Hahn, Vieira Lucia
机构信息
Instituto de Pesquisa e Desenvolvimento, Universidade do Vale do Paraíba, Avenida Shishima Hifumi, 2911, Urbanova, São José dos Campos 12244-000, SP, Brazil.
Biotechnology and Biodiversity Research Center, State University of Piaui, R. Lucídio Freitas, 2791-Matinha, Teresina 64003-120, PI, Brazil.
出版信息
Eur Burn J. 2025 Apr 8;6(2):18. doi: 10.3390/ebj6020018.
BACKGROUND
The wound healing process presents notable challenges for nursing teams, requiring extensive knowledge of wound care materials. A nanoparticle-free, bioabsorbable pol-yvinyl alcohol (PVA) with citric acid (CA) dressing produced by simple electrospin-ning was evaluated to treat acute wound healing in rats. This PVA-CA combination promotes crosslinking, increases the dressing capacity of absorption and confers heal-ing properties due to the citric acid antioxidant action.
METHODS
The dressing was tested in a quantitative experiment on 1.9 cm acute dermatological lesions in rats ( = 12), com-paring the PVA-CA-treated group with the untreated control group (CG). Samples were collected at 3, 7 and 14 days after lesion induction to evaluate the inflammatory process and tissue healing.
RESULTS
The macroscopic and histological data on the third day showed similar characteristics in both groups; however, after fourteen days, the PVA-CA group exhibited complete healing, accompanied by recomposition of the skin layers, whereas the wounds in the CG did not close completely.
CONCLUSIONS
The results highlight that electrospun PVA-AC dressings improve healing outcomes and constitute a prom-ising and affordable solution, providing a suitable environment for tissue repair, re-ducing inflammatory cell infiltration, blood vessel formation, and restoration of epi-thelial tissue, reducing the time of the healing process of acute wounds.
背景
伤口愈合过程给护理团队带来了显著挑战，需要对伤口护理材料有广泛的了解。对一种通过简单静电纺丝制备的不含纳米颗粒、可生物吸收的聚乙烯醇（PVA）与柠檬酸（CA）敷料进行了评估，以治疗大鼠急性伤口愈合。这种PVA-CA组合促进交联，增加敷料的吸收能力，并由于柠檬酸的抗氧化作用而具有愈合特性。
方法
在大鼠1.9厘米急性皮肤损伤的定量实验中对该敷料进行测试（n = 12），将PVA-CA治疗组与未治疗的对照组（CG）进行比较。在损伤诱导后第3、7和14天收集样本，以评估炎症过程和组织愈合情况。
结果
第三天的宏观和组织学数据显示两组具有相似特征；然而，十四天后，PVA-CA组实现了完全愈合，伴有皮肤层的重新组成，而CG组的伤口未完全闭合。
结论
结果表明，静电纺丝PVA-AC敷料改善了愈合效果，构成了一种有前景且经济实惠的解决方案，为组织修复提供了适宜环境，减少了炎症细胞浸润、血管形成以及上皮组织的恢复，缩短了急性伤口的愈合时间。
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