Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Pharmaceutical Sciences and Cosmetic Products Research Center, Kerman University of Medical Sciences, Kerman, Iran; Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Mater Sci Eng C Mater Biol Appl. 2020 Apr;109:110521. doi: 10.1016/j.msec.2019.110521. Epub 2019 Dec 6.
Worldwide research on electrospinning enabled it as a versatile technique for producing nanofibers with specified physio-chemical characteristics suitable for diverse biomedical applications. In the case of tissue engineering and regenerative medicine, the nanofiber scaffolds' characteristics are custom designed based on the cells and tissues specific needs. This fabrication technique is also innovated for the production of nanofibers with special micro-structure and secondary structure characteristics such as porous fibers, hollow structure, and core- sheath structure. This review attempts to critically and succinctly capture the vast number of developments reported in the literature over the past two decades. We then discuss their applications as scaffolds for induction of cells growth and differentiation or as architecture for being used as graft for tissue engineering. The special nanofibers designed for improving regeneration of several tissues including heart, bone, central nerve system, spinal cord, skin and ocular tissue are introduced. We also discuss the potential of the electrospinning in drug delivery applications, which is a critical factor for cell culture, tissue formation and wound healing applications.
全球范围内对静电纺丝的研究使其成为一种通用技术，可用于生产具有特定物理化学特性的纳米纤维，适用于各种生物医学应用。在组织工程和再生医学中，纳米纤维支架的特性是根据细胞和组织的具体需求定制设计的。这种制造技术还创新用于生产具有特殊微观结构和二级结构特征的纳米纤维，如多孔纤维、中空结构和芯-壳结构。本文综述试图批判性和简洁地捕捉过去二十年来文献中报道的大量进展。然后，我们讨论了它们作为诱导细胞生长和分化支架的应用，或作为用于组织工程的移植物的结构。介绍了为改善包括心脏、骨骼、中枢神经系统、脊髓、皮肤和眼部组织在内的几种组织的再生而设计的特殊纳米纤维。我们还讨论了静电纺丝在药物输送应用中的潜力，这对于细胞培养、组织形成和伤口愈合应用是一个关键因素。
