Globally, salt stress is one of the most significant abiotic stresses limiting crop production in dry-land regions. Nowadays, growing crops in dry-land regions under saline irrigation is the main focus. Soil amendment with organic materials has shown the potential to mitigate the adverse effects of salinity on plants. This study aimed to examine the ameliorative impact of soil amendment (manure + sandy, compost + sandy, clay + sandy and sandy soil) on the growth, yield, physiological, and biochemical attributes of Fisch. et Mey (HS) and L. (OT) under fresh and saline water irrigation in dry-land regions. The results showed that salt stress negatively affected both plant species' growth, physiological traits, yield, and chloride ions. In response to saline irrigation, plants of both species increased catalase (CAT) and ascorbate peroxidase (APX) activities as part of a self-defense mechanism to minimize damage. Salt stress also significantly raised levels of hydrogen peroxide (HO), malondialdehyde (MDA), and chloride ions (Cl). However, soil amendment treatments like manure + sandy and compost + sandy soil countered the negative effects of saline irrigation, significantly improving plant growth and yield compared with sandy soil. Thus, organic soil amendment is a promising strategy for sustainable crop production under saline irrigation in dry-land regions. This study provides valuable insights into enhancing agricultural production by fostering resilient halophytes and salt-tolerant plant species in challenging environments.