Caprioli J, Spaeth G L
Arch Ophthalmol. 1985 Aug;103(8):1145-9. doi: 10.1001/archopht.1985.01050080057020.
The optic nerves of 34 eyes of 34 patients with low-tension glaucoma were compared with those of 41 eyes of 41 patients with high-tension glaucoma. Mean intraocular pressure in the low-tension group was 16.9 +/- 0.7 mm Hg (mean +/- SEM) compared with 31.7 +/- 0.8 mm Hg in the high-tension group. Mean total visual field loss was not significantly different in the two groups, as determined by computerized threshold perimetry (OCTOPUS). The optic disc rim in low-tension eyes was significantly thinner than in high-tension eyes (P = .018); the largest difference occurred inferiorly and inferotemporally (P less than .001). The appearance of the optic nerve is useful to distinguish between these two subtypes of glaucoma and may be a more meaningful indicator than intraocular pressure. Our findings support the hypothesis that there are at least two different mechanisms for optic nerve damage in glaucoma.
对34例低眼压性青光眼患者的34只眼的视神经与41例高眼压性青光眼患者的41只眼的视神经进行了比较。低眼压组的平均眼压为16.9±0.7 mmHg（平均值±标准误），而高眼压组为31.7±0.8 mmHg。通过电脑阈值视野计（OCTOPUS）测定，两组的平均总视野缺损无显著差异。低眼压眼的视盘边缘明显比高眼压眼薄（P = 0.018）；最大差异出现在下方和颞下象限（P < 0.001）。视神经的外观有助于区分这两种青光眼亚型，并且可能是比眼压更有意义的指标。我们的研究结果支持这样的假设，即青光眼视神经损伤至少有两种不同的机制。
