Kishi S, Tso M O, Hayreh S S
Arch Ophthalmol. 1985 Aug;103(8):1189-97. doi: 10.1001/archopht.1985.01050080101029.
Experimental hypertensive choroidopathy was studied in 29 eyes from 15 monkeys in which accelerated renovascular systemic hypertension developed after a modified Goldblatt procedure. We followed up the animals from five days to 21 months to examine clinically and histopathologically the spectrum of the pathologic process. The pathologic features of hypertensive choroidopathy in our animals may be categorized into three phases: (1) Acute ischemic phase: The initial change in the choroidal vasculature was constriction of arterioles, which leads to focal necrosis of the choriocapillaris and the retinal pigment epithelium and focal subretinal exudate. (2) Chronic occlusive phase: Occlusive changes involving arteries, arterioles, and choriocapillaris occurred later. (3) Chronic reparative phase: With time, recanalization took place at all levels of the choroidal vasculature. The subretinal fluid was reabsorbed, leaving diffuse patchy depigmentation of the retinal pigment epithelium, which followed lobular arrangement of the choriocapillaris. Arteriolization of the choriocapillaris developed; this seems to be a defense mechanism to withstand the elevated systemic blood pressure.
对15只猴子的29只眼睛进行了实验性高血压脉络膜病变研究，这些猴子在改良的戈德布拉特手术后出现了加速性肾血管性全身性高血压。我们对这些动物进行了5天至21个月的随访，以便从临床和组织病理学角度检查病理过程的范围。我们实验动物中高血压脉络膜病变的病理特征可分为三个阶段：（1）急性缺血期：脉络膜血管系统的最初变化是小动脉收缩，这导致脉络膜毛细血管和视网膜色素上皮的局灶性坏死以及局灶性视网膜下渗出。（2）慢性闭塞期：动脉、小动脉和脉络膜毛细血管的闭塞性变化随后出现。（3）慢性修复期：随着时间的推移，脉络膜血管系统各层面都发生了再通。视网膜下液被吸收，留下视网膜色素上皮的弥漫性斑片状色素脱失，其与脉络膜毛细血管的小叶排列一致。脉络膜毛细血管出现动脉化；这似乎是一种抵御全身血压升高的防御机制。
