Walter R J, Danielson J R
Arch Otolaryngol. 1985 Aug;111(8):538-40. doi: 10.1001/archotol.1985.00800100086013.
The function of the immune surveillance system has been studied extensively in patients with neoplastic disease. Defective monocyte chemotaxis has been demonstrated in a variety of neoplastic conditions. We have assayed chemotaxis in monocytic and polymorphonuclear leukocytes taken from patients with epidermoid tumors of the head and neck. Multiwell chemotaxis chambers and the chemoattractant, formyl-methionyl-leucyl-phenylalanine, were used. Polymorphonuclear leukocytes responded normally, but monocytes from all tumor patients studied displayed marked reductions in random migration (86% inhibition) and in chemotaxis (77% inhibition) toward formylpeptide.
免疫监视系统的功能已在肿瘤疾病患者中得到广泛研究。在多种肿瘤情况下已证实单核细胞趋化性存在缺陷。我们对头颈部表皮样肿瘤患者的单核细胞和多形核白细胞的趋化性进行了检测。使用了多孔趋化性小室和趋化因子甲酰甲硫氨酰亮氨酰苯丙氨酸。多形核白细胞反应正常，但所有研究的肿瘤患者的单核细胞对甲酰肽的随机迁移（抑制率86%）和趋化性（抑制率77%）均显著降低。
