Leipzig B, Zellmer J E, Klug D
Arch Otolaryngol. 1985 Sep;111(9):589-94. doi: 10.1001/archotol.1985.00800110067004.
In a prospective multi-institutional study of 384 patients undergoing endoscopy, an 8.9% incidence of second primary neoplasms was discovered simultaneously in the lung (3.3%), esophagus (1.8%), and other head and neck sites (3.6%). The endoscopy was the only source of detection of these tumors in 58% of cases. A trend indicates that flexible fiberoptic bronchoscopy was more effective than rigid bronchoscopy in discovering lung tumors (7.5% vs 2.3%). Nevertheless, the chest roentgenogram remains an important tool in the diagnosis of second primary lesions in the lung. Panendoscopy is safe, takes little time, and can add invaluable information concerning therapy in patients with head and neck cancers.
在一项对384例接受内镜检查患者的前瞻性多机构研究中，同时发现第二原发性肿瘤的发生率为8.9%，其中肺部为3.3%，食管为1.8%，其他头颈部部位为3.6%。在58%的病例中，内镜检查是这些肿瘤的唯一检测来源。一种趋势表明，在发现肺部肿瘤方面，可弯曲纤维支气管镜比硬质支气管镜更有效（7.5%对2.3%）。然而，胸部X线片仍然是诊断肺部第二原发性病变的重要工具。全内镜检查安全、耗时少，可为头颈癌患者的治疗提供宝贵信息。
