组蛋白变体：一次一个氨基酸地扩展神经元的表观遗传潜能。
Histone variants: expanding the epigenetic potential of neurons one amino acid at a time.
作者信息
Lukasak Bradley J, Korb Erica
机构信息
Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
出版信息
Trends Biochem Sci. 2025 Jun;50(6):532-543. doi: 10.1016/j.tibs.2025.03.015. Epub 2025 Apr 22.
Replication-independent histone variants play an essential role in postmitotic neurons. Here, we review how the subtle sequence differences of histone variants compared to their canonical counterparts underly neuronal function. We focus on variants H3.3, H2A.Z, H2A.X, macroH2A, and H2BE; all of which contain divergent sequences that coordinate a diverse set of outcomes. In particular, we highlight their role in neuronal development, plasticity, and memory, with an emphasis on how single amino acid changes can mediate these complex functions. Lastly, we comment on an emerging field of study evaluating the link between histone variants and neurological disorders. Future studies of histone variants will be important to furthering our understanding of neuronal function.
不依赖复制的组蛋白变体在有丝分裂后的神经元中发挥着至关重要的作用。在此，我们回顾了与它们的经典对应物相比，组蛋白变体的细微序列差异是如何构成神经元功能基础的。我们重点关注变体H3.3、H2A.Z、H2A.X、macroH2A和H2BE；所有这些变体都包含不同的序列，这些序列协调了一系列不同的结果。特别地，我们强调它们在神经元发育、可塑性和记忆中的作用，重点关注单个氨基酸变化如何介导这些复杂功能。最后，我们对评估组蛋白变体与神经系统疾病之间联系的一个新兴研究领域发表评论。组蛋白变体的未来研究对于加深我们对神经元功能的理解将具有重要意义。
Zotero 插件