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本文引用的文献

1
The ABCs of the H2Bs: The histone H2B sequences, variants, and modifications.H2B蛋白的基础要素：组蛋白H2B序列、变体及修饰
Trends Genet. 2025 Feb 20. doi: 10.1016/j.tig.2025.01.003.
2
Histone variant H2BE enhances chromatin accessibility in neurons to promote synaptic gene expression and long-term memory.组蛋白变体 H2BE 增强神经元中的染色质可及性，以促进突触基因表达和长时程记忆。
Mol Cell. 2024 Aug 8;84(15):2822-2837.e11. doi: 10.1016/j.molcel.2024.06.025. Epub 2024 Jul 17.
3
Role of the histone variant H2A.Z.1 in memory, transcription, and alternative splicing is mediated by lysine modification.组蛋白变体 H2A.Z.1 在记忆、转录和选择性剪接中的作用是由赖氨酸修饰介导的。
Neuropsychopharmacology. 2024 Jul;49(8):1285-1295. doi: 10.1038/s41386-024-01817-2. Epub 2024 Feb 16.
4
The histone chaperone ANP32B regulates chromatin incorporation of the atypical human histone variant macroH2A.组蛋白伴侣 ANP32B 调控非典型人类组蛋白变体 macroH2A 的染色质掺入。
Cell Rep. 2023 Oct 31;42(10):113300. doi: 10.1016/j.celrep.2023.113300. Epub 2023 Oct 19.
5
Histone 3.3-related chromatinopathy: missense variants throughout H3-3A and H3-3B cause a range of functional consequences across species.组蛋白 3.3 相关染色质病：H3-3A 和 H3-3B 中的错义变体在物种间引起一系列功能后果。
Hum Genet. 2024 Apr;143(4):497-510. doi: 10.1007/s00439-023-02536-2. Epub 2023 Mar 3.
6
Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation.Tip60 介导的 H2A.Z 乙酰化促进神经元命运特化和二价基因激活。
Mol Cell. 2022 Dec 15;82(24):4627-4646.e14. doi: 10.1016/j.molcel.2022.11.002. Epub 2022 Nov 22.
7
Postmitotic accumulation of histone variant H3.3 in new cortical neurons establishes neuronal chromatin, transcriptome, and identity.新生皮质神经元中组蛋白变体 H3.3 的后有丝分裂积累建立了神经元染色质、转录组和身份。
Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2116956119. doi: 10.1073/pnas.2116956119. Epub 2022 Aug 5.
8
The role of histone modifications: from neurodevelopment to neurodiseases.组蛋白修饰的作用：从神经发育到神经疾病。
Signal Transduct Target Ther. 2022 Jul 6;7(1):217. doi: 10.1038/s41392-022-01078-9.
9
Histone macroH2A1 is a stronger regulator of hippocampal transcription and memory than macroH2A2 in mice.组蛋白 macroH2A1 比 macroH2A2 更能调节小鼠海马体的转录和记忆。
Commun Biol. 2022 May 19;5(1):482. doi: 10.1038/s42003-022-03435-4.
10
Histone H3.3 phosphorylation promotes heterochromatin formation by inhibiting H3K9/K36 histone demethylase.组蛋白 H3.3 磷酸化通过抑制 H3K9/K36 组蛋白去甲基化酶促进异染色质形成。
Nucleic Acids Res. 2022 May 6;50(8):4500-4514. doi: 10.1093/nar/gkac259.

组蛋白变体：一次一个氨基酸地扩展神经元的表观遗传潜能。

Histone variants: expanding the epigenetic potential of neurons one amino acid at a time.

作者信息

Lukasak Bradley J, Korb Erica

机构信息

Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

出版信息

Trends Biochem Sci. 2025 Jun;50(6):532-543. doi: 10.1016/j.tibs.2025.03.015. Epub 2025 Apr 22.

DOI:10.1016/j.tibs.2025.03.015
PMID:40268580
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12145244/
Abstract

Replication-independent histone variants play an essential role in postmitotic neurons. Here, we review how the subtle sequence differences of histone variants compared to their canonical counterparts underly neuronal function. We focus on variants H3.3, H2A.Z, H2A.X, macroH2A, and H2BE; all of which contain divergent sequences that coordinate a diverse set of outcomes. In particular, we highlight their role in neuronal development, plasticity, and memory, with an emphasis on how single amino acid changes can mediate these complex functions. Lastly, we comment on an emerging field of study evaluating the link between histone variants and neurological disorders. Future studies of histone variants will be important to furthering our understanding of neuronal function.

摘要

不依赖复制的组蛋白变体在有丝分裂后的神经元中发挥着至关重要的作用。在此，我们回顾了与它们的经典对应物相比，组蛋白变体的细微序列差异是如何构成神经元功能基础的。我们重点关注变体H3.3、H2A.Z、H2A.X、macroH2A和H2BE；所有这些变体都包含不同的序列，这些序列协调了一系列不同的结果。特别地，我们强调它们在神经元发育、可塑性和记忆中的作用，重点关注单个氨基酸变化如何介导这些复杂功能。最后，我们对评估组蛋白变体与神经系统疾病之间联系的一个新兴研究领域发表评论。组蛋白变体的未来研究对于加深我们对神经元功能的理解将具有重要意义。