Li Haoyuan, Zhu Zhenqi, Li Yuqiao, Xia Weiwei, Zhao Chong, Guo Chen, Xu Shuai, Liu Haiying
Department of Spinal Surgery, Peking University People's Hospital, Peking University, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, P.R. China.
Beijing HuaSheng Rehabilitation Hospital, No.1 Guangcai Road, Fengtai District, Beijing, 100075, P.R. China.
J Orthop Surg Res. 2025 Apr 23;20(1):410. doi: 10.1186/s13018-025-05713-3.
There are few researches on characterizing the sagittal alignment of degenerative thoracolumbar kyphosis (DTLK). In addition, the debate on the reasonable surgical strategies, for various patterns of DTLK, still continues. So, the study was to identify the features of DTLK, propose a novel classification of DTLK, and develop surgical strategies for this population.
An overall 245 patients diagnosed with DTLK combined with lumbar stenosis performed surgeries (acquired satisfied) were selected from January 2016 to December 2022. The spino-pelvic measurements thoracic kyphosis (TK), thoracolumbar kyphosis (TLK), lumbar lordosis (LL), pelvic incidence (PI), pelvic tilt (PT), sagittal vertical axis (SVA) as well as the severe osteoporosis were recorded. To identify groups with similar spino-pelvic sagittal alignment parameters and clinical features, a 2-step cluster analysis was performed.
Close relationships were found among the parameters. Four types of DTLK based on TLK and balance were classified with Type I: mild kyphosis and balance, Type II: mild kyphosis and imbalance, Type III: severe kyphosis and balance, Type IV: severe kyphosis and imbalance. The probability for imbalance with severe osteoporosis was 8.4 times higher than no osteoporosis (RR = 8.410). The probability for imbalance with PI-LL mismatch was 10 times higher than PI-LL matching (RR = 0.099 in Type II and RR = 0.103 in Type IV). For patients with DTLK, the TK was correlated with LL, PI-LL or PI in Type I to III group but not in Type IV group. Targeted treatment strategies for different types of patients was then addressed.
We proposed a novel classifcation with four types of DTLK based on TLK and balance, followed by targeted treatment strategies for various types. Osteoporosis and lumbo-pelvic mismatch were risk factors for DTLK imbalance.
关于退行性胸腰椎后凸畸形(DTLK)矢状面排列特征的研究较少。此外,针对不同类型DTLK的合理手术策略的争论仍在继续。因此,本研究旨在明确DTLK的特征,提出一种新的DTLK分类方法,并为该人群制定手术策略。
选取2016年1月至2022年12月期间诊断为DTLK合并腰椎管狭窄并接受手术(获得满意效果)的245例患者。记录脊柱-骨盆测量指标,包括胸椎后凸(TK)、胸腰椎后凸(TLK)、腰椎前凸(LL)、骨盆入射角(PI)、骨盆倾斜角(PT)、矢状垂直轴(SVA)以及严重骨质疏松情况。为确定具有相似脊柱-骨盆矢状面排列参数和临床特征的组,进行了两步聚类分析。
发现各参数之间存在密切关系。基于TLK和平衡情况将DTLK分为四种类型:I型:轻度后凸且平衡;II型:轻度后凸且失衡;III型:重度后凸且平衡;IV型:重度后凸且失衡。伴有严重骨质疏松时失衡的概率比无骨质疏松时高8.4倍(相对危险度RR = 8.410)。伴有PI-LL不匹配时失衡的概率比PI-LL匹配时高10倍(II型中RR = 0.099,IV型中RR = 0.103)。对于DTLK患者,I至III组中TK与LL、PI-LL或PI相关,而IV组中则无相关性。随后针对不同类型患者提出了靶向治疗策略。
我们基于TLK和平衡情况提出了一种新的DTLK四种类型分类方法,随后针对不同类型制定了靶向治疗策略。骨质疏松和腰骨盆不匹配是DTLK失衡的危险因素。